PMID: 7030951Jul 1, 1981Paper

Role of reactive hyperreninemia in blood pressure changes induced by sodium depletion in patients with refractory hypertension

Hypertension
H GavrasI Gavras

Abstract

Sixteen patients with refractory hypertension were submitted to vigorous sodium depletion while cardiovascular homeostasis was monitored with measurements of hormonal and hemodynamic parameters and repeat saralasin tests. This regimen resulted in a negative sodium balance by an average of 300 mEq. The loss of sodium closely correlated to the decrease of body weight (r = 0.70, p less than 0.005). Blood pressure (BP) decreased from 176/166 +/- 8/3 to 155/109 +/-6/3 mm Hg. There was a significant correlation between percent increments in plasma renin activity (PRA) and the rise in plasma norepinephrine (r = 0.68, p less than 0.05) and a close negative correlation between percent increase in PRA and the ratio of fall in mean blood pressure (MAP) per unit of weight loss (r = -0.73, p less than 0.005). Thus, patients with the least percent increase in PRA demonstrated the greatest fall in BP per unit of weight loss, indicating that relative rather than absolute elevation of renin may be the factor limiting antihypertensive efficacy of sodium depletion. Sodium depletion induced increase in peripheral resistance and decrease in cardiac output, both mostly attributable to relative hyperreninemia. Indeed, the adverse hemodynamic changes ...Continue Reading

References

Jul 5, 1979·The New England Journal of Medicine·N K HollenbergG H Williams
Jan 1, 1979·British Journal of Clinical Pharmacology·H R BrunnerI Gavras
Dec 2, 1976·The New England Journal of Medicine·H GavrasH R Brunner
Feb 1, 1975·Life Sciences·D P HenryR H Williams
Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Apr 1, 1972·Kidney International·J E SealeyJ H Laragh
May 1, 1974·Kidney International·A MimranN K Hollenberg
Apr 20, 1972·The New England Journal of Medicine·H P DustanE L Bravo
Aug 22, 1980·Science·P HatzinikolaouI Gavras

❮ Previous
Next ❯

Citations

Oct 1, 1988·Journal of Steroid Biochemistry·B WaeberH R Brunner
Oct 22, 1982·Pharmaceutisch Weekblad. Scientific Edition·W Soudijn
Aug 18, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajiv Agarwal
Nov 1, 1993·Clinical and Experimental Hypertension : CHE·H R BrunnerB Waeber
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·H Gavras
Jun 29, 1989·The New England Journal of Medicine
May 1, 1981·Circulation Research·P A JohnstonN G Levinsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.