Role of reactive oxygen species in regulation of glucose transport in skeletal muscle during exercise

The Journal of Physiology
Abram Katz

Abstract

Glucose derived from extracellular sources serves as an energy source in virtually all eukaryotic cells, including skeletal muscle. Its contribution to energy turnover increases with exercise intensity up to moderately heavy workloads. However, at very high workloads, the contribution of extracellular glucose to energy turnover is negligible, despite the high rate of glucose transport. Reactive oxygen species (ROS) are involved in the stimulation of glucose transport in isolated skeletal muscle preparations during intense repeated contractions. Consistent with this observation, heavy exercise is associated with significant production of ROS. However, during more mild to moderate stimulation or exercise conditions (in vitro, in situ and in vivo) antioxidants do not affect glucose transport. It is noteworthy that the production of ROS is limited or not observed under these conditions and that the concentration of the antioxidant used was extremely low. The results to date suggest that ROS involvement in activation of glucose transport occurs primarily during intense short-term exercise and that other mechanisms are involved during mild to moderate exercise. What remains puzzling is why ROS-mediated activation of glucose transport...Continue Reading

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Citations

Feb 15, 2018·Medical Sciences : Open Access Journal·Manuela CervelliPaolo Mariottini
May 24, 2017·Cold Spring Harbor Perspectives in Medicine·Mark Hargreaves, Lawrence L Spriet
Sep 27, 2018·Advances in Nutrition·Nikos V MargaritelisMichalis G Nikolaidis
Oct 8, 2019·Antioxidants & Redox Signaling·Carlos Henríquez-OlguínThomas E Jensen
Mar 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Tong XingXinglian Xu
Feb 9, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sarah J BlackwoodAbram Katz

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