Role of reactive oxygen species (ROS) and JNKs in selenite-induced apoptosis in HepG2 cells

Cancer Biology & Therapy
Durga P Cherukuri, Mark A Nelson

Abstract

Dietary selenium (Se) supplementation has been shown to be effective against reducing the risk of incidence of different human cancers. Selenium exists in both organic and inorganic forms. Different chemical forms of selenium metabolize differently in vivo, activate distinct molecular mechanisms and exhibit varying degree of anti-carcinogenicity in different cancer types. The effectiveness of a Se compound could also vary depending on the genetic background of the tumor cells. Therefore, understanding the molecular mechanism(s) by which different Se compounds exert their anti-tumorigenic effects is necessary for their use in cancer chemoprevention.

Citations

Jun 19, 2013·Biological Trace Element Research·Pei GuoYanli Liu
May 13, 2008·Biochimica Et Biophysica Acta·Assunta LombardiFernando Goglia
Jan 2, 2018·Acta orthopaedica et traumatologica turcica·Dong-Yeong LeeDong-Hee Kim
May 16, 2020·Frontiers in Pharmacology·Yinhuan ZhangHongbin Xiao

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