PMID: 30814082Mar 1, 2019Paper

Role of Red Blood Cell Distribution Width in Predicting Cardiac Syndrome X in Women

Annals of Clinical and Laboratory Science
Kai Zhao, Yongjian Li

Abstract

To investigate whether the increased red blood cell distribution width (RDW) is a biomarker for predicting the presence of cardiac syndrome X (CSX) in women. 110 CSX women patients and 98 normal controls were prospectively enrolled in this study. The CSX group consisted of patients with anginal chest pain, ischemia on noninvasive stress test and a normal coronary angiography. The control group was selected from the patients with anginal symptoms but those who had a normal stress test and a normal coronary angiography. Blood samples were drawn from all women patients for measuring RDW and C-reactive protein (CRP). Then the baseline data were compared between CSX patients and normal controls. Baseline characteristics of the two groups were similar. The serum RDW levels and CRP levels were significantly higher in the CSX group than those in the normal control group (P<0.01). Patients with CSX had higher diabetes mellitus (DM) and menopausal rates (P<0.05). In a multivariate analysis, RDW levels, CRP levels and DM were associated independently with CSX in women. Serum RDW level may independently predict CSX in women, which indicates that a chronic inflammatory response might be involved in the pathogenesis of CSX.

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