Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases.

Frontiers in Immunology
Ning HuangJie Qiao

Abstract

Regulatory T cells (Tregs) are a specialized subset of T lymphocytes that function as suppressive immune cells and inhibit various elements of immune response in vitro and in vivo. While there are constraints on the number or function of Tregs which can be exploited to evoke an effective anti-tumor response, sufficient expansion of Tregs is essential for successful organ transplantation and for promoting tolerance of self and foreign antigens. The immune-suppressive property of Tregs equips this T lymphocyte subpopulation with a pivotal role in the establishment and maintenance of maternal tolerance to fetal alloantigens, which is necessary for successful pregnancy. Elevation in the level of pregnancy-related hormones including estrogen, progesterone and human chorionic gonadotropin promotes the recruitment and expansion of Tregs, directly implicating these cells in the regulation of fetal-maternal immune tolerance. Current studies have provided evidence that a defect in the number or function of Tregs contributes to the etiology of several reproductive diseases, such as recurrent spontaneous abortion, endometriosis, and pre-eclampsia. In this review, we provide insight into the underlying mechanism through which Tregs contribu...Continue Reading

References

Feb 3, 1997·The Journal of Experimental Medicine·P A van der MerweS J Davis
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B F BeboH Offner
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·X ZhangH L Weiner
Feb 28, 2002·Human Reproduction Update·Thomas M D'Hooghe, Sophie Debrock
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimito KawahataKazuhiko Yamamoto
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song Guo ZhengDavid A Horwitz
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
May 16, 2003·American Journal of Obstetrics and Gynecology·Jon I EinarssonMichael O Gardner
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kary A LathamEdward F Rosloniec
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Jul 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Silke PaustHarvey Cantor
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magdalena J PolanczykHalina Offner
Nov 16, 2004·Lancet·Linda C Giudice, Lee C Kao
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samuel HuberManfred Blessing
Mar 9, 2005·The Journal of Experimental Medicine·Allison L BayerThomas R Malek
Mar 23, 2005·Immunity·Jason D FontenotAlexander Y Rudensky
Apr 6, 2005·The Journal of Experimental Medicine·Julien C MarieAlexander Y Rudensky
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felicita BaratelliSteven M Dubinett
Oct 26, 2005·Nature Immunology·Karsten KretschmerHarald von Boehmer
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Tamsin M Lindström, Phillip R Bennett
Dec 17, 2005·European Journal of Immunology·Ana C ZenclussenHans-Dieter Volk
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc A GavinAlexander Y Rudensky
Aug 15, 2006·Immunological Reviews·David M Sansom, Lucy S K Walker
Aug 15, 2006·Lancet·Raj Rai, Lesley Regan
Sep 20, 2006·Human Reproduction Update·Hanna Achache, Ariel Revel

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean section
RSA
flow cytometry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Creg J WorkmanDario A A Vignali
Immunological Investigations
Masoud H Manjili, Kyle K Payne
© 2021 Meta ULC. All rights reserved