Role of renal prostaglandins in sympathetically mediated renin relase in the rat

The Journal of Clinical Investigation
W B CampbellE K Jackson


Renal prostaglandins (PG) appear to mediate renin release due to stimulation of the intrarenal baroreceptor, but not that due to activation of the macula densa. However, as the role of PG in sympathetically mediated renin release remains unclear, a possible interrelationship between these factors was examined in conscious rats. Hydralazine increased the serum renin levels from 3.1+/-0.8 to 16.7+/-3.0 ng/ml per h at a dose of 1 mg/kg. Indomethacin (5 mg/kg) suppressed urinary PGE(2) and PGF(2alpha) excretion by 89 and 74%, respectively, arachidonate hypotension by 82%, and inhibited the elevated renin levels from hydralazine by 100% without altering the hypotensive effect of the drug. Another PG synthetase inhibitor, meclofenamate, was also effective in attenuating hydralazine-induced renin release, urinary PGE(2) and PGF(2alpha) excretion, and arachidonate hypotension. Isoproterenol, a nonselective beta-adrenergic agonist, increased heart rate, lowered blood pressure, and also stimulated the release of renin when administered intraperitoneally. However, intrarenal infusion of the drug only resulted in increased renin release. Indomethacin inhibited isoproterenol-induced renin release by 66 and 67%, respectively, without alterin...Continue Reading


Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Nov 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·T OkaharaK Yamamoto
Feb 1, 1975·The Journal of Clinical Investigation·W A Pettinger, K Keeton
Feb 2, 1978·Nature·P M BolgerL M Slotkoff
Nov 21, 1977·Biochemical and Biophysical Research Communications·T V ZenserB B Davis
May 31, 1976·The American Journal of Medicine·M P FichmanR Rude
Sep 1, 1976·Circulation Research·J C FrölichJ A Oates
May 1, 1977·Circulation Research·J YunH Smith
Jun 16, 1977·Nature·P M BolgerL M Slotkoff
Aug 1, 1976·The Journal of Clinical Investigation·J C RomeroC G Strong
Oct 1, 1976·Circulation Research·M S GolubR Horton
Mar 1, 1975·Kidney International·V E TorresD M Wilson
Jul 1, 1975·British Journal of Pharmacology·B B Fredholm, P Hedqvist
Jul 29, 1975·European Journal of Clinical Investigation·F DrayJ Maclouf
Mar 1, 1973·European Journal of Pharmacology·S BergströmK Fuxe
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·A M MichelakisG W Liddle
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A M Michelakis, R G McAllister
Oct 1, 1974·European Journal of Pharmacology·C LarssonE Anggård


Jan 1, 1985·European Journal of Clinical Pharmacology·E J SainsburyJ J Ashley
Sep 1, 1980·Pflügers Archiv : European journal of physiology·U KoppB Ablad
Sep 15, 1982·Klinische Wochenschrift·J C Frölich, G Fejes-Toth
Jun 15, 1984·European Journal of Pharmacology·D D Smyth, H Y Fung
Jan 27, 1984·European Journal of Pharmacology·S L Pfister, T K Keeton
Sep 15, 1986·Life Sciences·W L HenrichW B Campbell
Jul 20, 1987·Life Sciences·W L HenrichW B Campbell
Dec 1, 1980·Prostaglandins·R Franco-SaenzS Y Tan
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·G A LopezM Natividad
May 1, 1982·Clinical and Experimental Pharmacology & Physiology·W P Anderson
Nov 1, 1984·Clinical and Experimental Pharmacology & Physiology·R T MasonB A Scoggins
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·I W ReimannJ C Frölich
Dec 1, 1979·The Journal of Clinical Investigation·W B CampbellH D Itskovitz
Oct 1, 1986·The Journal of Clinical Investigation·A OhnishiE K Jackson
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·M Suzuki, S Satoh
Nov 1, 1980·Kidney International·M J Dunn, E J Zambraski
Jan 1, 1981·Kidney International·M J Dunn
Feb 1, 1982·The American Journal of Medicine·D J LevensonB M Brenner
Mar 1, 1982·Progress in Cardiovascular Diseases·R R MillerM A Quinones
Jun 1, 1985·British Journal of Pharmacology·R Lew, R J Summers
Apr 26, 1985·The American Journal of Cardiology·J T Shepherd
May 1, 1982·Hypertension·R H FreemanS F Echtenkamp
Jan 1, 1984·Circulation Research·R H FreemanD Villarreal
Aug 1, 1988·Hypertension·A OhnishiE K Jackson
Apr 1, 1987·British Journal of Obstetrics and Gynaecology·S SaarikoskiO Castrén
Jan 1, 1980·British Journal of Pharmacology·W B CampbellW A Pettinger
Oct 15, 1981·Klinische Wochenschrift·J C Frölich
Mar 1, 1981·The American Journal of Physiology·S SuzukiP J Mulrow

Related Concepts

Adrenergic beta-Agonists
Eicosatetraenoic Acids
Diastolic Blood Pressure
Bucladesine, Barium (1: 1) Salt
Pulse Rate

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.