Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats

The Journal of Pharmacology and Experimental Therapeutics
John H DubinionE K Jackson

Abstract

The purpose of this study was to test the hypothesis that renal sympathetic nerves modulate angiotensin II-induced renal vasoconstriction in kidneys from genetically hypertensive rats via Y1 receptors activating the Gi pathway. In isolated, perfused kidneys from spontaneously hypertensive rats, the naturally occurring renal sympathetic cotransmitter neuropeptide Y at 6 nM enhanced angiotensin II (0.3 nM)-induced changes in perfusion pressure by 47 +/- 7 mm Hg, and this effect was inhibited by BIBP3226 [N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)-methyl]-D-arginine amide)], a selective Y1 receptor antagonist (1 microM). We next examined whether periarterial nerve stimulation (5 Hz) enhances renal vascular responses to a physiological level of angiotensin II (100 pM). Kidneys were pretreated with prazosin (a selective alpha1-adrenoceptor antagonist) to block nerve stimulation-induced changes in perfusion pressure. In kidneys from spontaneously hypertensive rats, but not normotensive rats, periarterial nerve stimulation significantly augmented angiotensin II-induced changes in perfusion pressure (177 +/- 26% of response in absence of stimulation). BIBP3226, but not rauwolscine (a selective alpha2-adrenoceptor antagonist), abolished p...Continue Reading

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May 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Edwin K JacksonChongxue Zhu

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Citations

May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Anwar UmarNicholas Moore
Apr 9, 2010·Clinical and Experimental Pharmacology & Physiology·David S TofovicEdwin K Jackson
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mirnela BykuThomas C Westfall
Nov 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mirnela BykuThomas C Westfall
Feb 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bharathy Ponnuchamy, Raouf A Khalil
Nov 25, 2011·American Journal of Physiology. Renal Physiology·Edwin K JacksonZaichuan Mi
Jan 20, 2017·American Journal of Physiology. Renal Physiology·Xiao Zhu, Edwin K Jackson
Nov 5, 2014·Hypertension·Edwin K JacksonDelbert G Gillespie
Aug 31, 2006·Hypertension·William H Beierwaltes
Dec 7, 2007·The Journal of Pharmacology and Experimental Therapeutics·Jo G R De MeyGregorio E Fazzi

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