Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion.

Journal of the American Society of Nephrology : JASN
Hayo CastropA Kurtz

Abstract

This study aimed to assess the role of cyclooxygenase-2 (COX-2)-derived prostanoids for the macula densa control of renal afferent arteriolar resistance and for renin secretion. For this purpose, studied were the effects of blocking macula densa salt transport by the loop diuretic bumetanide (100 microM) on renal perfusate flow and on renin secretion in isolated perfused rats, in which renocortical COX-2 expression was prestimulated in vivo by treatment with the angiotensin-converting enzyme inhibitor ramipril, with low-salt diet, or with a combination of both. These maneuvers stimulated COX-2 expression in an order of ramipril + low salt>> low salt > ramipril > controls. Flow rates through isolated kidneys at a constant pressure of 100 mmHg were dependent on the pretreatment regimen, in the way that they went in parallel with COX-2 expression. The COX-2 inhibitor NS-398 (10 microM) lowered flow rates depending on the COX-2 expression level and was most pronounced therefore after pretreatment with low salt + ramipril. NS-398 did not change the increase of flow in response to bumetanide but attenuated the stimulation of renin secretion in response to bumetanide in a manner depending on the expression level of COX-2. These findin...Continue Reading

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Citations

Nov 16, 2002·The Journal of Laboratory and Clinical Medicine·Radko KomersSharon Anderson
Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Miet Schetz
Apr 29, 2004·American Journal of Physiology. Renal Physiology·Frank SchwedaArmin Kurtz
Jul 14, 2004·Hypertension·Jorge A RodriguezNicholas R Ferreri
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May 5, 2005·Medicine and Science in Sports and Exercise·Jordan BakerRobert J Walker
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Raymond C Harris, Matthew D Breyer
Dec 29, 2005·American Journal of Physiology. Renal Physiology·Hui-Fang ChengRaymond C Harris
Jun 21, 2006·Journal of Cardiovascular Pharmacology·Raymond C Harris
Apr 8, 2006·Physiological Reviews·Linda J MullinsJohn J Mullins
Jan 16, 2007·Journal of Pharmacological Sciences·Sirinun NilwarangkoonHitoshi Endou
Mar 16, 2007·Kidney International·C-M Hao, M D Breyer
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charlotte WagnerKlaus Höcherl
Nov 9, 2007·Annual Review of Physiology·Chuan-Ming Hao, Matthew D Breyer
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Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Jun 1, 2008·Electrolyte & Blood Pressure : E & BP·Gheun-Ho Kim

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