Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients

Nutrients
Marta Cosín-TomàsCoral Sanfeliu

Abstract

Oxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer's disease (AD). Studies have shown that the brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid cell lines (LCLs) from AD patients and HCs to investigate the role of resveratrol (RV) and selenium (Se) in the reduction of reactive oxygen species (ROS) generated after an oxidative injury. We also studied whether these compounds elicited expression changes in genes involved in the antioxidant cell response and other aging-related mechanisms. AD LCLs showed higher ROS levels than those from HCs in response to H2O2 and FeSO4 oxidative insults. RV triggered a protective response against ROS under control and oxidizing conditions, whereas Se exerted antioxidant effects only in AD LCLs under oxidizing conditions. RV increased the expression of genes encoding known antioxidants (catalase, copper chaperone for superoxide dismutase 1, glutathione S-transferase zeta 1) and anti-aging factors (sirtuin 1 and sirtuin 3) in both AD and HC LCLs. Our findings support RV as a candidate for inducing resilience and protection against AD, and reinforce the v...Continue Reading

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Citations

Sep 15, 2020·Metallomics : Integrated Biometal Science·Yukari NakanoKen-Ichiro Tanaka
Mar 19, 2020·International Journal of Molecular Medicine·Yun ZhangXing Wang
May 5, 2020·Frontiers in Aging Neuroscience·Bruno Dutra ArboMariana Appel Hort
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Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Dan-Dan ZhouHua-Bin Li
Sep 1, 2021·Biological Trace Element Research·Hai-Bing YangShang Mao
Nov 20, 2021·Frontiers in Cardiovascular Medicine·Baohui YuanLi-Long Pan

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Methods Mentioned

BETA
Assay
protein
Protein Assay

Software Mentioned

GraphPad
GraphPad Prism

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