Role of rhenium-188 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions refractory to conventional therapy

Nuclear Medicine Communications
S A ShamimArun Malhotra

Abstract

To evaluate the treatment response of rhenium-188 (¹⁸⁸Re) tin colloid radiosynovectomy (¹⁸⁸Re-RSV) in patients with inflammatory knee joint conditions refractory to conventional treatment. Sixty-one knee joints in 48 patients with chronic synovitis caused by various inflammatory knee joint diseases refractory to conventional therapy were included in this prospective study. All patients were assessed clinically for pain, tenderness, joint swelling, mobility, analgesic intake, and blood pool activity on bone scan. Different scores were assigned to all these parameters. RSV of knee joint was done using intra-articular injection of 555 MBq of ¹⁸⁸Re tin colloid. Response was assessed at 3, 6, and 12 months using various clinical parameter scores and blood pool bone scan mentioned above and categorized as responders and nonresponders on the basis of change in percentage of cumulative scores. Of the 61 joints, 57 were responder and four were nonresponder at 3-month post-RSV. Out of 57 responders, seven had recurrence on further follow-up (three at 6 months and four at 12 months). There was a statistically significant reduction in clinical parameters cumulative scores at 3, 6, and 12 months when compared with baseline (P<0.0001) in res...Continue Reading

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Citations

Jan 13, 2012·Australasian Physical & Engineering Sciences in Medicine·Alberto E Hardy-PérezNallely P Jiménez-Mancilla
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