Role of rhinovirus load in the upper respiratory tract and severity of symptoms in lung transplant recipients

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Juan AmbrosioniLaurent Kaiser

Abstract

Rhinovirus is the most common cause of respiratory viral infections and leads to frequent respiratory symptoms in lung transplant recipients. However, it remains unknown whether the rhinovirus load correlates with the severity of symptoms. This study aimed to better characterize the pathogenesis of rhinoviral infection and the way in which viral load correlates with symptoms. We assessed rhinovirus load in positive upper respiratory specimens of patients enrolled prospectively in a cohort of 116 lung transplant recipients. Rhinovirus load was quantified according to a validated in-house, real-time, reverse transcription polymerase chain reaction in pooled nasopharyngeal and pharyngeal swabs. Symptoms were recorded in a standardised case report form completed at each screening/routine follow-up visit, or during any emergency visit occurring during the 3-year study. Rhinovirus infections were very frequent, including in asymptomatic patients not seeking a specific medical consultation. Rhinovirus load ranged between 4.1 and 8.3 log copies/ml according to the type of visit and clinical presentation. Patients with highest symptom scores tended to have higher viral loads, particularly those presenting systemic symptoms. When conside...Continue Reading

References

Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Patrick MalliaSebastian L Johnston
Apr 5, 2011·Archives of Virology·Cristina CostaRossana Cavallo
Apr 28, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D-L VuL Kaiser
May 16, 2012·Journal of Medical Virology·Aya TakeyamaMitsuaki Hosoya
May 25, 2012·Influenza and Other Respiratory Viruses·Cristian LaunesCarmen Muñoz-Almagro
Jun 22, 2012·Journal of Clinical Microbiology·Manuel SchiblerCaroline Tapparel
Nov 29, 2012·Chest·Elisabeth KieningerNicolas Regamey
Jul 31, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S EspositoN Principi
Jan 3, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J AmbrosioniL Kaiser

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Citations

Nov 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Andrea H L BruningDasja Pajkrt
May 13, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C LaunesC Muñoz-Almagro
Apr 17, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kak-Ming LingAnthony Kicic
Sep 13, 2019·Clinical Microbiology Reviews·Michael G Ison, Hans H Hirsch
Feb 26, 2020·BMC Infectious Diseases·Marie DubertFrançois-Xavier Lescure
Jul 21, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Evan AmmermanLara Danziger-Isakov
Aug 5, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Katrina BazemorePali D Shah
May 31, 2019·Current Opinion in Organ Transplantation·Hannah H Nam, Michael G Ison
Dec 12, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alpana WaghmareWendy M Leisenring

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