Role of RIP140 in metabolic tissues: connections to disease

FEBS Letters
Roger WhiteMalcolm G Parker


The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle metabolism, adipocyte and hepatocyte function, and reproduction. Recent evidence has shown that the ability of RIP140 to regulate nuclear receptor function is determined by the relative level of RIP140 expression in comparison with other cofactors, by post-translational modifications and by interactions with additional transcription factors. As a result it is becoming apparent that RIP140, via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state.


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Related Concepts

Metabolic Process, Cellular
Ovarian Diseases
Diabetes Mellitus, Non-Insulin-Dependent
NRIP1 wt Allele
Biochemical Pathway
Insulin Sensitivity
PPARA wt Allele
Co-Repressor Proteins
NRIP1 protein, human

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