Role of saliva in esophageal defense: implications in patients with nonerosive reflux disease

The American Journal of the Medical Sciences
Harathi YandrapuJ Sarosiek

Abstract

It has been previously demonstrated that patients with reflux esophagitis exhibit a significant impairment in the secretion of salivary protective components versus controls. However, the secretion of salivary protective factors in patients with nonerosive reflux disease (NERD) is not explored. The authors therefore studied the secretion of salivary volume, pH, bicarbonate, nonbicarbonate glycoconjugate, protein, epidermal growth factor (EGF), transforming growth factor alpha (TGF-α) and prostaglandin E2 in patients with NERD and compared with the corresponding values in controls (CTRL). Salivary secretion was collected during basal condition, mastication and intraesophageal mechanical (tubing, balloon) and chemical (initial saline, acid, acid/pepsin, final saline) stimulations, respectively, mimicking the natural gastroesophageal reflux. Salivary volume, protein and TGF-α outputs in patients with NERD were significantly higher than CTRL during intraesophageal mechanical (P < 0.05) and chemical stimulations (P < 0.05). Salivary bicarbonate was significantly higher in NERD than CTRL group during intraesophageal stimulation with both acid/pepsin (P < 0.05) and saline (P < 0.01). Salivary glycoconjugate secretion was significantly...Continue Reading

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Citations

Oct 28, 2016·Annals of the New York Academy of Sciences·Vincenzo Di PilatoPaolo Bechi
Jul 1, 2020·Terapevticheskiĭ arkhiv·V T IvashkinM I Gonik
Nov 1, 2020·Annals of the New York Academy of Sciences·C Prakash GyawaliJerzy Sarosiek
Oct 9, 2019·Best Practice & Research. Clinical Gastroenterology·Serhat Bor
Feb 17, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Tomohide TanabeKatsuhiko Iwakiri
Oct 12, 2020·Biochemical Pharmacology·Bianca N QuadeRossana Occhipinti
Apr 23, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Mai KoedaKatsuhiko Iwakiri
Sep 19, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Mai KoedaKatsuhiko Iwakiri

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