Role of SAM Chain Length in Enhancing the Sensitivity of Nanopillar Modified Electrodes for Glucose Detection.

Sensors
Venkataramani AnandanGuigen Zhang

Abstract

In this report, alkanethiol self assembled monolayers (SAM) with two different chain lengths were used to immobilize the functionalizing enzyme (glucose oxidase) onto gold nanopillar modified electrodes and the electrochemical processes of these functionalized electrodes in glucose detection were investigated. First, the formation of these SAMs on the nanopillar modified electrodes was characterized by the cyclic voltammetry and electrochemical impedance spectroscopy techniques, and then the detection sensitivity of these functionalized electrodes to glucose was evaluated by the amperometry technique. Results showed that the SAM of alkanethiols with a longer chain length resulted in a higher degree of surface coverage with less defect and a higher electron transfer resistance, whereas the SAM of alkanethiols with a shorter chain length gave rise to a higher detection sensitivity to glucose. This study sheds some new insight into how to enhance the sensing performance of nanopillar modified electrodes.

References

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Apr 26, 2003·Biosensors & Bioelectronics·Marc Delvaux, Sophie Demoustier-Champagne
Aug 28, 2007·International Journal of Nanomedicine·Venkataramani AnandanGuigen Zhang
Feb 15, 2008·Journal of Biological Engineering·Venkataramani AnandanGuigen Zhang

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Citations

Oct 31, 2009·Journal of the American Chemical Society·Libo HuKevin D Moeller
Apr 27, 2011·ACS Applied Materials & Interfaces·Jonathan C ClaussenD Marshall Porterfield
Jul 20, 2012·Biosensors & Bioelectronics·Elizabeth Schneider, Douglas S Clark
Oct 27, 2011·Analytica Chimica Acta·Vijayender Bhalla, Valter Zazubovich
Apr 22, 2010·Angewandte Chemie·Jun-Ichi Yoshida, Aiichiro Nagaki
Aug 28, 2009·Biosensors & Bioelectronics·Seokheun Choi, Junseok Chae
May 4, 2016·Applied Microbiology and Biotechnology·Airis Maria Araújo MeloCarlúcio R Alves
May 25, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Chun WangXin Jiang
Nov 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Chenglong XuXuehua Zhang
Dec 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing WanSongqin Liu
Oct 21, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Dara Bobb-SempleStacey F Bent

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