Role of scavenger receptors in dendritic cell function

Human Immunology
Dan WangShujian Ge

Abstract

Dendritic cells (DCs), the most potent of the antigen-presenting cells, are crucial in initiating and shaping innate and adaptive immune responses. DCs discriminate unmodified self antigens from non-self and altered/modified self antigens via a large family of receptors called pattern-recognition receptors, which include Toll-like receptors and scavenger receptors (SRs). Recent findings underscore the critical role of SRs on DCs in pathogen clearance, atherosclerosis, apoptotic cell recognition, diesel exhaust particle recognition, etc. These new findings present SRs as an unexplored therapeutic target that warrants further basic and applied research, and have implications for vaccine development. This review highlights recent insights into the emerging role of these receptors in DC-mediated immune responses.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Aug 17, 1999·Biochemical and Biophysical Research Communications·C BuechlerG Schmitz
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·B C UrbanD J Roberts
Jan 16, 2002·Current Opinion in Immunology·Leanne PeiserSiamon Gordon
Aug 13, 2003·The Journal of Biological Chemistry·Birke BartoschFrançois-Loïc Cosset
Oct 22, 2003·The Journal of Experimental Medicine·Virginie DoyenMarika Sarfati
Oct 16, 2004·Immunobiology·Subhankar Mukhopadhyay, Siamon Gordon
Feb 4, 2005·Nature·Kasper HoebeBruce Beutler
Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
May 21, 2005·Atherosclerosis·Jane E MurphySreenivasan Ponnambalam
Sep 15, 2005·The Journal of Experimental Medicine·Daniele AccapezzatoVincenzo Barnaba
Mar 28, 2007·JAMA : the Journal of the American Medical Association·Jean-Claude TardifUNKNOWN Effect of rHDL on Atherosclerosis-Safety and Efficacy (ERASE) Investigators
Jul 17, 2007·American Journal of Respiratory Cell and Molecular Biology·Michael PorterMarc A Williams
Oct 9, 2007·Methods : a Companion to Methods in Enzymology·Annette PlüddemannSiamon Gordon
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana MarukianLynn B Dustin
Jan 31, 2009·The Lancet Infectious Diseases·Daniel P WebsterKatie J M Jeffery
Apr 25, 2009·Cellular Microbiology·Thomas Areschoug, Siamon Gordon
Oct 9, 2009·Autoimmunity·Marijo ParcinaIsabelle Bekeredjian-Ding
Nov 12, 2010·Virchows Archiv : an International Journal of Pathology·Colin-John Perrins, Yuri V Bobryshev
Dec 6, 2011·Annual Review of Immunology·Ralph M Steinman
Dec 22, 2011·Malaria Journal·Peter W GethingSimon I Hay
Jul 4, 2012·Circulation Research·Marietta HerrmannWilli Jahnen-Dechent
Aug 22, 2012·Current Opinion in Lipidology·Chieko Mineo, Philip W Shaul
May 1, 2013·Critical Reviews in Immunology·Carolina ArmengolMaria-Rosa Sarrias
Aug 10, 2013·Nature Reviews. Immunology·Johnathan CantonSergio Grinstein

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Citations

Nov 8, 2015·Advanced Drug Delivery Reviews·Laura NorthrupCory Berkland
Nov 30, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qian ShiZong-Lai Jiang
Jan 12, 2019·Frontiers in Immunology·Daniel A Patten, Shishir Shetty
May 30, 2020·Nanomaterials·Ximena ZottigSteve Bourgault
Jul 15, 2016·Clinical Microbiology Reviews·Pablo F CéspedesSusan M Bueno
Jul 13, 2021·The Journal of Biological Chemistry·Chen ChengYongning He

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