Role of secondary attachment sites in changing the specificity of site-specific recombination.

Journal of Bacteriology
Edit RutkaiR A Weisberg

Abstract

We previously proposed that lambdoid phages change their insertion specificity by adapting their integrases to sequences found in secondary attachment sites. To test this model, we quantified recombination between partners that carried sequences from secondary attachment sites catalyzed by wild-type and by mutant integrases with altered specificities. The results are consistent with the model, and indicate differential core site usage in excision and integration.

Citations

May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Asaf TalJoel Stavans
Feb 2, 2021·FEMS Microbiology Reviews·Catherine BadelJacques Oberto
May 1, 2021·Microorganisms·Olivier ClaisseClaire Le Marrec
Jun 25, 2015·Microbiology Spectrum·Arthur Landy

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