Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Antioxidants
Izhar Hyder QaziGuang-Bin Zhou

Abstract

Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in mice). As an essential component of selenoproteins, Se performs structural and enzymic roles; in the latter context it is well known for its catalytic and antioxidative functions. Studies involving different animal models have added great value to our understanding regarding the potential implications of Se and selenoproteins in mammalian fertility and reproduction. In this review, we highlight the implications of selenoproteins in male fertility and reproduction followed by the characteristic biological functions of Se and selenoproteins associated with overall male reproductive function. It is evident from observations of past studies (both animal and human) that Se is essentially required for spermatogenesis and male fertility, presumably because of its vital role in modulation of antioxidant defense mechanisms and other essential biological pathways and redox sensitive transcription factors. However, bearing in mind the evidences from mainstream literature, it is also advisable t...Continue Reading

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Citations

Dec 12, 2019·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
Oct 3, 2020·Environmental Science and Pollution Research International·Ekaterina PavlovaJuliana Ivanova
Mar 28, 2020·Environmental Science and Pollution Research International·Ahmed S MandourGen Watanabe
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Oct 9, 2020·Animal Reproduction·Inmaculada ParrillaCristina Alicia Martinez
Oct 9, 2020·BMC Genomics·Liang JiangYan Zhang
Nov 15, 2020·Biological Trace Element Research·Muhammad Adeel ArshadFaiz-Ul Hassan
Jan 9, 2021·Biological Trace Element Research·Qin WangZhen-Wu Huang
Apr 16, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Javad SeyediJamshid Amiri Moghadam
Apr 26, 2021·Biological Trace Element Research·Samson O AdeniranGuixue Zhang
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Jun 22, 2021·Frontiers in Nutrition·Rannapaula Lawrynhuk Urbano FerreiraLucia Fatima Campos Pedrosa

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Methods Mentioned

BETA
MDA

Software Mentioned

SELENOP

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