PMID: 9525296Apr 3, 1998Paper

Role of sensory innervation and mast cells in neurogenic plasma protein exudation into the airway lumen

Respirology : Official Journal of the Asian Pacific Society of Respirology
M L KowalskiM A Kaliner

Abstract

Neurogenic inflammation in the airways involves both mucosal oedema and plasma protein exudation into the airway lumen. We aimed to investigate the mechanism of exudation of plasma proteins into the airway lumen. Neurogenic inflammation was induced in anaesthetized Sprague-Dawley rats by electrical stimulation of both vagal nerves at 20 V, 10 Hz, 5 ms. Vascular permeability was measured as 125I-albumin extravasation into both the airway wall and tracheobronchial lavage fluid. Following vagal stimulation, tracheobronchial lavages were analysed for albumin, total protein, histamine, immunoreactive substance P (SP), and immunoreactive calcitonin gene-related peptide (CGRP). Vagal stimulation rapidly increased vascular permeability in the airway mucosa and induced exudation of plasma proteins into the tracheobronchial fluid. Pre-treatment with capsaicin inhibited both neurogenic vascular permeability and movement of albumin into the airway lumen. SP and CGRP were detectable in basal lavages (1.37+/-0.12 ng/mL and 2.17+/-0.21 ng/mL, respectively) and the concentration of SP fell by 43% following treatment with capsaicin. Following vagal stimulation, concentrations of both SP and CGRP decreased significantly. Although basal tracheobr...Continue Reading

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Citations

May 5, 2012·European Journal of Pharmacology·Tatsuo SakamotoMio Miyake
Jun 19, 2004·International Archives of Allergy and Immunology·Osamu MukaiyamaMakoto Yamashita
Jun 8, 2001·Psychological Bulletin·A KüblerN Birbaumer

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