Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.

European Journal of Pharmacology
Rashida PachmerhiwalaGary A Gudelsky

Abstract

The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The relationship of these responses to the hyperthermia produced by MDMA also was examined. The administration of MDMA (10mg/kg, i.p.) resulted in a significant and sustained increase of 65-100% in the extracellular concentration of glucose in the striatum, as well as in the prefrontal cortex and hippocampus, and a 35% decrease in brain glycogen content. Peripheral blood glucose was modestly increased by 32% after MDMA treatment. Treatment of rats with fluoxetine (10mg/kg, i.p.) significantly attenuated the MDMA-induced increase in extracellular glucose in the striatum but had no effect on MDMA-induced glycogenolysis or hyperthermia. Treatment with prazosin (1mg/kg, i.p.) did not alter the glucose or glycogen responses to MDMA but completely suppressed MDMA-induced hyperthermia. Finally, propranolol (3mg/kg, i.p.) significantly attenuated the MDMA-induced increase in extracellular glucose and glycogenolysis but did not al...Continue Reading

References

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Jun 2, 2009·European Journal of Pharmacology·Matthew L BanksJon E Sprague

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Citations

Apr 28, 2011·The Journal of Physiology·Takashi MatsuiHideaki Soya
Mar 6, 2015·International Journal of High Risk Behaviors & Addiction·Mohammad Reza Shahraki, Mahdieh Irani
Jun 28, 2018·Metabolic Brain Disease·Yanhong ZhangHonghong Yao
Oct 29, 2014·Journal of Animal Science·R L DennisD C Lay
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi

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