PMID: 6974213Sep 1, 1981Paper

Role of serotonin in the regulation of growth hormone and prolactin secretion in the domestic fowl

The Journal of Endocrinology
J RabiiC G Scanes

Abstract

Plasma levels of GH and prolactin were measured by radioimmunoassay in male domestic fowl treated with centrally active agents. p-Chlorophenylalanine (pCPA) did not have an effect on tonic levels of prolactin but led to a significant rise in circulating GH concentrations. The three serotonin receptor antagonists tested, methysergide, SQ-10631 and cyproheptadine, each resulted in a significant reduction in plasma prolactin while markedly increasing plasma GH levels. Administration of 5-hydroxytryptophan led to a rise in plasma prolactin and a drop in plasma GH levels in untreated birds or in animals pretreated with pCPA. The serotonin receptor agonist, quipazine, resulted in a marked increase in plasma prolactin and a marked reduction in plasma GH concentrations in untreated birds. In pCPA-pretreated animals quipazine was no longer effective in altering plasma prolactin levels but still caused a significant drop in circulating levels of GH. These results suggest that in the young male domestic fowl serotonin has a stimulatory role in the regulation of prolactin and an inhibitory role in the regulation of GH secretion.

Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·T R HallC G Scanes
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T R HallS Harvey
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·F C BuonomoC G Scanes
Oct 20, 1999·Domestic Animal Endocrinology·M ZemanE Decuypere
May 7, 2013·European Journal of Nutrition·Paola CastrogiovanniRosa Imbesi
May 22, 2009·Annals of the New York Academy of Sciences·Manuel D GaheteJusto P Castaño
Dec 1, 1983·General and Comparative Endocrinology·S C FehrerM E El Halawani
May 1, 1986·General and Comparative Endocrinology·T R HallA Chadwick
Jun 1, 1984·General and Comparative Endocrinology·M E El HalawaniE J Behnke
Jun 1, 1984·General and Comparative Endocrinology·F C BuonomoC G Scanes
Dec 1, 1984·The Journal of Experimental Zoology·P J SharpT R Hall
Dec 1, 1984·The Journal of Experimental Zoology·M E El HalawaniB M Hargis
Dec 1, 1984·The Journal of Experimental Zoology·C G Scanes, T J Lauterio

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