Role of serum carcinoembryonic antigen in the detection of colorectal cancer before and after surgical resection.

World Journal of Gastroenterology : WJG
Bin-Bin SuJun Wan

Abstract

To determine whether serum levels of carcinoembryonic antigen (CEA) correlate with the presence of primary colorectal cancer (CRC), and/or recurrent CRC following radical resection. A total of 413 patients with CRC underwent radical surgery between January 1998 and December 2002 in our department and were enrolled in this study. The median follow-up period was 69 mo (range, 3-118 mo), and CRC recurrence was experienced by 90/413 (21.8%) patients. Serum levels of CEA were assayed preoperatively, and using a cutoff value of 5 ng/mL, patients were divided into two groups, those with normal serum CEA levels (e.g., ≤ 5 ng/mL) and those with elevated CEA levels (> 5 ng/mL). The overall sensitivity of CEA for the detection of primary CRC was 37.0%. The sensitivity of CEA according to stage, was 21.4%, 38.9%, and 41.7% for stages I-III, respectively. Moreover, for stage II and stage III cases, the 5-year disease-free survival rates were reduced for patients with elevated preoperative serum CEA levels (P < 0.05). The overall sensitivity of CEA for detecting recurrent CRC was 54.4%, and sensitivity rates of 36.6%, 66.7%, and 75.0% were associated with cases of local recurrence, single metastasis, and multiple metastases, respectively. In...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M PignatelliW F Bodmer
Aug 1, 1981·The American Journal of Medicine·R GoslinN Zamcheck
Mar 10, 2001·Trends in Microbiology·S Hammarström, V Baranov
Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J DuffyO Topolcan
Oct 22, 2008·Human Gene Therapy·Federica MoriLuigi Aurisicchio
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Dec 24, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A E M van der PoolC Verhoef
Mar 23, 2011·Journal of the National Cancer Institute·Pragatheeshwar ThirunavukarasuDavid L Bartlett

❮ Previous
Next ❯

Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Jian HePing Yang
Jul 19, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L ChenX Su
Dec 25, 2015·International Journal of Surgery·Caspar G SørensenJacob Rosenberg
Aug 8, 2015·Journal of Computer Assisted Tomography·Michael J ReiterMichael B Osswald
Jun 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Renato FalzaranoEmanuela Anastasi
Aug 13, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Michael GadeLars J Petersen
Oct 29, 2013·Journal of Immunological Methods·Heather P OstendorffMark J Lim
Mar 22, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S L RasmussenO Thorlacius-Ussing
Feb 25, 2018·Proteomics. Clinical Applications·Juhura G AlmaziMatthew D Dun
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Brian D NicholsonDavid Mant
Sep 13, 2017·Frontiers in Pharmacology·Kha Wai HonRahman Jamal
Jul 12, 2018·Journal of Cancer Research and Clinical Oncology·David H MurraySusanne K Pedersen
Dec 27, 2016·Proteomics. Clinical Applications·Claudia CorboFrancesco Salvatore
Aug 9, 2018·Frontiers in Oncology·Hariti SalujaErin L Symonds
May 7, 2020·Journal of Internal Medicine·C ShiR A de Boer
Apr 1, 2020·Journal of Immunoassay & Immunochemistry·Wafaa M ElzefzafyNesreen Atef
Dec 1, 2018·Abdominal Radiology·S C FariaP R Bhosale
Jan 29, 2021·Biosensors & Bioelectronics·Shazana Hilda ShamsuddinPaul A Millner
May 1, 2021·International Journal of Molecular Sciences·Donatella VerbanacKarmela Barišić
Jan 25, 2019·ACS Applied Materials & Interfaces·Xin ZhouNing Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
David A BrownElaine Lanza
Cancer Immunology, Immunotherapy : CII
Miriam ReuschenbachNicolas Wentzensen
© 2021 Meta ULC. All rights reserved