Role of several Staphylococcus aureus virulence factors on the inflammatory response in bovine mammary gland

Microbial Pathogenesis
Alfonso ZecconiRenata Piccinini

Abstract

Staphylococcus aureus causes many serious diseases in humans and animals, and it is the most common aetiologic agent of contagious bovine mastitis. The bacteria produce several virulence factors and the importance of evaluating the combination of these virulence factors has been recently emphasized. In study, the combination of several virulence factors: coagulase gene (coa), protein A gene (spa), collagen-binding protein gene (cna), fibrinogen-binding protein gene (efb), Panton-Valentin leukocydin gene (pvl) and enterotoxins (sea,seb, sec, sed, see, seg, seh, sei, sej) was considered. The analysis of the relationship between presence/absence of the different genes and the udder inflammatory response measured by milk somatic cell counts was performed by general linear models and logistic regression. The classification of isolates in clusters by virulence genes combinations showed that at least one cluster induced a higher inflammatory response. Moreover, the analysis of the association between virulence genes and the presence of a subclinical mastitis showed the role of spa and sej gene as risk factors. These results support that the development of subclinical mastitis could be related to strains characteristics and to the expr...Continue Reading

References

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May 25, 2005·The Journal of Dairy Research·Alfonso ZecconiRenata Piccinini
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Jul 13, 2005·Cellular Microbiology·Bettina Haslinger-LöfflerBhanu Sinha

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Citations

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Mini Bharathan, Isis K Mullarky
Oct 17, 2008·The Journal of Dairy Research·Renata PiccininiAlfonso Zecconi
Mar 1, 2012·The Journal of Dairy Research·Renata PiccininiMuna F Anjum
Jun 24, 2008·Journal of Bacteriology·Nouri L Ben ZakourYves Le Loir
Apr 14, 2012·The Veterinary Journal·Olga Wellnitz, Rupert M Bruckmaier
Feb 7, 2013·World Journal of Microbiology & Biotechnology·M H Fabres-KleinA O B Ribon
Mar 18, 2011·International Journal of Food Microbiology·José C SoaresManuela M Pintado
Apr 24, 2010·Veterinary Microbiology·Renata PiccininiAlfonso Zecconi
Apr 7, 2007·Veterinary Immunology and Immunopathology·Carolina GómezJesús Ramírez
May 16, 2015·Research in Veterinary Science·F ScaliA Zecconi
Nov 20, 2012·Research in Veterinary Science·Margherita FestaAlfonso Zecconi
Sep 20, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Marcelo Fabiano Gomes BoriolloJosé Francisco Höfling
Sep 27, 2018·International Journal of Veterinary Science and Medicine·M N HoqueM A Islam

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