Role of sGC-dependent NO signalling and myocardial infarction risk

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Jana WobstHeribert Schunkert

Abstract

The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LamasT Michel
Mar 1, 1991·Trends in Pharmacological Sciences·M W RadomskiS Moncada
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J StuehrC F Nathan
Feb 15, 1991·Biochemical Pharmacology·L J Ignarro
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Nov 1, 1993·Cardiovascular Research·P C Ursell, M Mayes
Jun 1, 1995·Annals of Medicine·R Busse, I Fleming
Aug 1, 1995·Nature Medicine·J L ZweierP Kuppusamy
Jan 1, 1994·Advances in Pharmacology·T D WarnerF Murad
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·D J Stuehr
Jan 31, 1998·Biochemistry·Y Zhao, M A Marletta
May 16, 1998·Biochemical and Biophysical Research Communications·T TsukadaJ Igari
May 15, 1998·The New England Journal of Medicine·I GoldsteinP A Wicker
Sep 22, 1998·The Biochemical Journal·M RusswurmD Koesling
Oct 8, 1999·Biochemical and Biophysical Research Communications·J BudworthK Powell
Mar 10, 2001·Nature·J P StaschM Schramm
Jan 30, 2002·British Journal of Pharmacology·Johannes-Peter StaschMatthias Schramm
Jan 30, 2003·The EMBO Journal·Sergei D RybalkinJoseph A Beavo
May 3, 2003·Trends in Molecular Medicine·Matthew W FosterJonathan S Stamler
Dec 23, 2003·The International Journal of Biochemistry & Cell Biology·Hideaki Okamoto

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Citations

Sep 8, 2015·Biochimica Et Biophysica Acta·Sylvia HillerXianwen Yi
Sep 7, 2016·Atherosclerosis·Lingyao ZengHeribert Schunkert
May 11, 2017·Circulation·Thorsten KesslerHeribert Schunkert
Nov 1, 2018·Physiological Reviews·Jesús TejeroMark T Gladwin
Nov 30, 2019·Experimental and Therapeutic Medicine·Ghadir El SamadJalil Daher
Sep 3, 2020·International Journal of Molecular Sciences·Wolfgang KreiselPeter Deibert
Mar 16, 2021·Frontiers in Physiology·Krishan K VishnoliaJeanette Erdmann
May 4, 2021·Frontiers in Physiology·Pamela CzajkaMarek Postula

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