Role of SGT1 in resistance protein accumulation in plant immunity.

The EMBO Journal
Cristina AzevedoKen Shirasu

Abstract

A highly conserved eukaryotic protein SGT1 binds specifically to the molecular chaperone, HSP90. In plants, SGT1 positively regulates disease resistance conferred by many Resistance (R) proteins and developmental responses to the phytohormone, auxin. We show that silencing of SGT1 in Nicotiana benthamiana causes a reduction in steady-state levels of the R protein, Rx. These data support a role of SGT1 in R protein accumulation, possibly at the level of complex assembly. In Arabidopsis, two SGT1 proteins, AtSGT1a and AtSGT1b, are functionally redundant early in development. AtSGT1a and AtSGT1b are induced in leaves upon infection and either protein can function in resistance once a certain level is attained, depending on the R protein tested. In unchallenged tissues, steady-state AtSGT1b levels are at least four times greater than AtSGT1a. While the respective tetratricopeptide repeat (TPR) domains of SGT1a and SGT1b control protein accumulation, they are dispensable for intrinsic functions of SGT1 in resistance and auxin responses.

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Citations

Jun 20, 2012·Molecules and Cells·Jae-Hoon LeeChian Kwon
Aug 28, 2012·Nucleic Acids Research·Elke SchaperMaria Anisimova
Oct 17, 2009·Genes & Development·Noriyuki HatsugaiIkuko Hara-Nishimura
Dec 7, 2007·Plant Physiology·Jane Larkindale, Elizabeth Vierling
Aug 30, 2008·The Plant Cell·Ayako NakashimaKo Shimamoto
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Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jean da Silva CorreiaRichard Ulevitch
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yulei ShangJian-Min Zhou
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LorangThomas J Wolpert
Nov 19, 2008·Annual Review of Plant Biology·Ken Shirasu
Aug 19, 2007·Seminars in Immunopathology·Fabio MartinonJürg Tschopp
Mar 12, 2016·Genome Génome / Conseil National De Recherches Canada·Ashokraj ShanmugamIll-Sup Nou
Aug 19, 2009·The Plant Journal : for Cell and Molecular Biology·Doris BirkerRichard O'Connell
Jun 21, 2011·Current Opinion in Plant Biology·Saskia A Hogenhout, Jorunn I B Bos
Apr 5, 2011·Current Opinion in Plant Biology·James Mitch ElmoreGitta Coaker
Feb 16, 2011·Journal of Proteomics·Cândido P P RicardoPedro Fevereiro
Dec 8, 2009·European Journal of Cell Biology·Ulrike LipkaVolker Lipka
Apr 29, 2009·Seminars in Cell & Developmental Biology·Maryam RafiqiPeter N Dodds
Aug 8, 2008·Trends in Plant Science·David MeinkeAllan Dickerman
May 24, 2008·Current Opinion in Plant Biology·Ulrike LipkaVolker Lipka
Jul 24, 2007·Trends in Plant Science·Jens Staal, Christina Dixelius

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