Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy

Biological Chemistry
Tieying SongYunliang Yang

Abstract

The neurobiological mechanisms of obesity-induced peripheral neuropathy are poorly understood. We evaluated the role of Sigma-1 receptor (Sig-1R) and NMDA receptor (NMDARs) in the spinal cord in peripheral neuropathy using an animal model of high fat diet-induced diabetes. We examined the expression of Sig-1R and NMDAR subunits GluN2A and GluN2B along with postsynaptic density protein 95 (PSD-95) in the spinal cord after 24-week HFD treatment in both wild-type and Sig-1R-/- mice. Finally, we examined the effects of repeated intrathecal administrations of selective Sig-1R antagonists BD1047 in HFD-fed wild-type mice on peripheral neuropathy. Wild-type mice developed tactile allodynia and thermal hypoalgesia after 24-week HFD treatment. HFD-induced peripheral neuropathy correlated with increased expression of GluN2A and GluN2B subunits of NMDARs, PDS-95, and Sig-1R, as well as increased Sig-1R-NMDAR interaction in the spinal cord. In contrast, Sig-1R-/- mice did not develop thermal hypoalgesia or tactile allodynia after 24-week HFD treatment, and the levels of GluN2A, GluN2B, and PSD-95 were not altered in the spinal cord of HFD-fed Sig-1R-/- mice. Finally, repeated intrathecal administrations of selective Sig-1R antagonists BD10...Continue Reading

References

Apr 25, 1990·European Journal of Pharmacology·F P MonnetC De Montigny
Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox
Mar 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·R BergeronG Debonnel
May 31, 2002·Journal of Neurophysiology·Shao-Rui Chen, Hui-Lin Pan
Jan 15, 2003·Neurology·C J SumnerM Polydefkis
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Teruo Hayashi, Tsung-Ping Su
Mar 22, 2005·European Journal of Pharmacology·Cruz Miguel CendánJosé M Baeyens
Mar 29, 2005·Diabetes Care·Andrew J M BoultonUNKNOWN American Diabetes Association
Nov 11, 2005·Journal of the Peripheral Nervous System : JPNS·Giacinta MiscioAlessandro Mauro
Dec 14, 2007·Expert Opinion on Therapeutic Targets·Teruo Hayashi, Tsung-Ping Su
Dec 21, 2007·Nature Reviews. Neuroscience·David R Tomlinson, Natalie J Gardiner
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Gary L PittengerAaron I Vinik
Aug 30, 2008·The Journal of Pharmacology and Experimental Therapeutics·Yelenis HerreraJavier Cuevas
Dec 23, 2008·Behavioural Brain Research·Valentina SabinoEric P Zorrilla
Jul 14, 2009·Diabetes·Andrea M VincentEva L Feldman
Jul 22, 2009·Pharmacology & Therapeutics·Tangui Maurice, Tsung-Ping Su
Dec 22, 2009·Central Nervous System Agents in Medicinal Chemistry·Shang-Yi TsaiTsung-Ping Su
Sep 28, 2010·Trends in Pharmacological Sciences·Tsung-Ping SuArnold E Ruoho
Mar 8, 2011·Expert Opinion on Therapeutic Targets·Teruo HayashiTsung-Ping Su
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine L SalussoliaLonnie P Wollmuth
Oct 16, 2012·The Journal of Pain : Official Journal of the American Pain Society·Francisco Rafael NietoJosé Manuel Baeyens
Mar 19, 2013·European Journal of Pharmacology·Daniel ZamanilloJosé Miguel Vela
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dilshan BalasuriyaJ Michael Edwardson
May 31, 2014·Science·Erkan Karakas, Hiro Furukawa
Aug 22, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohan PabbaRichard Bergeron

❮ Previous
Next ❯

Methods Mentioned

BETA
co-immunoprecipitation
Co-IP
pharmacotherapies
Protein Assay
X-ray
immunoprecipitation

Software Mentioned

GraphPad Prism
NIH Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.