Role of sigmaD in regulating genes and signals during Myxococcus xanthus development.

Journal of Bacteriology
Poorna ViswanathanLee Kroos

Abstract

Starvation-induced development of Myxococcus xanthus is an excellent model for biofilm formation because it involves cell-cell signaling to coordinate formation of multicellular mounds, gene expression, and cellular differentiation into spores. The role of sigma(D), an alternative sigma factor important for viability in stationary phase and for stress responses, was investigated during development by measuring signal production, gene expression, and sporulation of a sigD null mutant alone and upon codevelopment with wild-type cells or signaling mutants. The sigD mutant responded to starvation by inducing (p)ppGpp synthesis normally but was impaired for production of A-signal, an early cell density signal, and for production of the morphogenetic C-signal. Induction of early developmental genes was greatly reduced, and expression of those that depend on A-signal was not restored by codevelopment with wild-type cells, indicating that sigma(D) is needed for cellular responses to A-signal. Despite these early developmental defects, the sigD mutant responded to C-signal supplied by codeveloping wild-type cells by inducing a subset of late developmental genes. sigma(D) RNA polymerase is dispensable for transcription of this subset, bu...Continue Reading

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Citations

May 13, 2008·Applied and Environmental Microbiology·Sarah M SowellStephen J Giovannoni
Dec 26, 2006·Journal of Bacteriology·Thomas M A Gronewold, Dale Kaiser
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Poorna ViswanathanLee Kroos
Dec 21, 2013·FEMS Microbiology Reviews·Anna KonovalovaLee Kroos
Nov 10, 2009·FEMS Microbiology Reviews·Anna KonovalovaLotte Søgaard-Andersen

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