Role of simian virus 40 in cancer incidence in solid organ transplant patients.

British Journal of Cancer
V ParacchiniE Taioli

Abstract

Transplant recipients have an increased risk of developing cancer in comparison with the general population. We present here data on cancer development in transplanted subjects who received organs from donors whose DNA was previously examined for the genomic insertion of Simian Virus 40 (SV40). Active follow-up of 387 recipients of solid organs donated by 134 donors, not clinically affected by cancer, was performed through the National Transplant Center (NTC). The average length of follow-up after transplant was 671+/-219 days (range 0-1085 days). Out of 134 proposed donors, 120 were utilised for organ donation. Of these, 12 (10%) were classified as positive for SV40 genomic insertion. None of the 41 recipients of organs from SV40 positive donors developed a tumour during the follow-up. In all, 11 recipients of organs given by SV40 negative donors developed a tumour (cancer incidence: 0.015 per year). In conclusion, cancer rates observed in our study are comparable to what reported by the literature in transplanted patients. Recipients of solid organs from SV40 positive donors do not have an increased risk of cancer after transplant. The role of SV40 in carcinogenesis in transplanted patients may be minimal.

References

Apr 9, 1992·The New England Journal of Medicine·D J BergsagelR L Garcea
Jan 1, 1974·Transplantation·K V ShahG P Murphy
Jan 29, 1999·Journal of the National Cancer Institute·J S Butel, J A Lednicky
Aug 7, 1999·The Journal of Infectious Diseases·J S ButelM J Finegold
Mar 27, 2001·Transplantation Proceedings·M CardilloUNKNOWN North Italy Transplant Program
Dec 1, 2001·Transplantation·E MylonakisJ A Fishman
Feb 19, 2002·Oncogene·George KleinCarlo Croce
Mar 19, 2002·Lancet·Regis A VilchezJanet S Butel
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Rui-Mei LiJeffrey B Kopp
Sep 28, 2002·Transplantation·Regis A VilchezShimon Kusne
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eun Jeong KwakShimon Kusne
Jan 2, 2003·Journal of the National Cancer Institute·Howard D StricklerPhilip S Rosenberg
Jun 12, 2003·The American Journal of Medicine·Regis A VilchezJanet S Butel
Jul 3, 2003·Journal of the National Cancer Institute·Jane MacKenzieRuth F Jarrett
Jul 15, 2003·Journal of Medical Virology·Wendy A KnowlesElizabeth Miller
Sep 17, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A Kazory, D Ducloux
Sep 26, 2003·Transplantation·Renaud SnanoudjBernard Charpentier
Oct 16, 2003·Journal of the National Cancer Institute·Joseph J CarterDenise A Galloway
Jul 21, 2005·Molecular Medicine·Valentina ParacchiniEmanuela Taioli
Jul 26, 2005·Transplantation·Randall J FaullStephen P McDonald
Aug 6, 2005·Mutation Research·Valentina ParacchiniEmanuela Taioli

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Citations

Sep 28, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Regis A Vilchez, Shimon Kusne

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Methods Mentioned

BETA
PCR

Software Mentioned

SAS

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