PMID: 9180152May 29, 1997Paper

Role of sinusoidal heparan sulfate proteoglycan in liver metastasis formation

International Journal of Cancer. Journal International Du Cancer
J TóváriJ Tímár

Abstract

Previous studies have indicated that the predominant sites of tumor cell extravasation in the liver are the sinusoidal vessels, where tumor cells contact the sinusoidal endothelium and the subendothelial extracellular matrix containing the basic components of the basement membrane. We studied the role of sinusoidal extracellular matrix in metastatsis formation by 3LL-HH murine tumor cells selected for their preferential liver colonization. 3LL-HH tumor cells did not efficiently adhere to cryosections of the liver, but they recognized the sinusoids and vessel walls. Pre-treatment of the mice with polyclonal anti-basement membrane antibodies [anti-laminin, anti-fibronectin and anti-heparan sulfate proteoglycan (HSPG)] significantly modulated the organ distribution of tumor cell colonies following intracardial injection: all 3 antibodies inhibited kidney colonization; anti-laminin and anti-fibronectin antibodies inhibited lung colonization; and only anti-HSPG antibody inhibited liver colonization. In several organs such as the heart, stomach, pancreas and bladder, anti-basement membrane antibody treatment did not alter the process of colonization. Immunofluorescence studies showed that anti-HSPG antibody recognized the basement me...Continue Reading

References

Mar 1, 1978·Journal of the National Cancer Institute·K P DingemansI V van de Pavert
Aug 1, 1991·Journal of Clinical Pathology·M R GriffithsA D Burt
Mar 8, 1991·Cell·E Ruoslahti, Y Yamaguchi
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·S PakuK Lapis
Oct 28, 1994·Biochemical and Biophysical Research Communications·H KovalszkyG Ramadori
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·A LadányiK Lapis

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Citations

Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xinnong Jiang, John R Couchman
Nov 3, 2001·Pathology Oncology Research : POR·J TímárL Kopper
Jan 5, 2006·Brain Pathology·Dongyan WangCandece L Gladson
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y Q Ma, J G Geng
Jul 3, 2002·Nature Reviews. Cancer·Ram SasisekharanUma Narayanasami
Apr 6, 2012·Clinical & Experimental Metastasis·Gert G Van den EyndenPeter B Vermeulen
Jan 15, 2000·La Revue de médecine interne·A PierresP Bongrand

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