Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome

The Journal of Immunology : Official Journal of the American Association of Immunologists
Masahiro SekiguchiHajime Sano

Abstract

Primary Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammatory mononuclear cell infiltration and destruction of epithelial cells of lacrimal and salivary glands. Sphingosine 1-phosphate (S1P) and signaling through its receptor S1P(1) have been implicated in many critical cellular events including inflammation, cancer, and angiogenesis. This study was undertaken to examine the role of S1P(1) signaling in the pathogenesis of primary SS. S1P(1) and sphingosine kinase 1, which converts sphingosine to S1P, were detected in the cytoplasm of inflammatory mononuclear cells, vascular endothelial cells, and epithelial cells in all labial salivary glands by immunohistochemistry. The expression of S1P(1) in inflammatory mononuclear cells was enhanced in advanced stages of primary SS. S1P enhanced proliferation and IFN-gamma production by CD4(+) T cells. The enhancing effect of S1P on IFN-gamma production by CD4(+) T cells was stronger in patients with primary SS than in healthy controls. S1P also enhanced Fas expression and Fas-mediated caspase-3 induction in salivary gland epithelial cells. IL-6 expression was detected in the cytoplasm of inflammatory mononuclear cells and ductal epithelial cells and was enhanced i...Continue Reading

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Citations

Mar 3, 2009·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Toshimitsu Fujii, Mamoru Watanabe
Aug 19, 2011·International Immunology·Xiang LinKalin Yanbo Zhang
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Apr 10, 2019·Thyroid : Official Journal of the American Thyroid Association·Cheng HanWeiping Teng
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Apr 27, 2021·Frontiers in Pharmacology·Weilin ChenHonglin Zhu

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