Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression.

Neuroreport
Bethany FitzsimmonsTony L Yaksh

Abstract

Pharmacological studies indicate that spinal p38 mitogen-activated protein kinase plays a role in the development of hyperalgesia. We investigated whether either the spinal isoform p38alpha or p38beta is involved in peripheral inflammation evoked pain state and increased expression of spinal COX-2. Using intrathecal antisense oligonucleotides, we show that hyperalgesia is prevented by downregulation of p38beta but not p38alpha, whereas increases in spinal COX-2 protein expression at 8 hours are mediated by both p38alpha and beta isoforms. These data suggest that early activation of spinal p38beta isoform may affect acute facilitatory processing, and both p38beta and alpha isoforms mediate temporally delayed upregulation of spinal COX-2.

References

Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S MudgettM M Shen
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Camilla I Svensson, Tony L Yaksh
Nov 28, 2002·Biological Chemistry·Yu Shi, Matthias Gaestel
Jun 27, 2003·The Journal of Biological Chemistry·Kotha SubbaramaiahAndrew J Dannenberg
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy
Mar 8, 2005·Journal of Neurochemistry·Camilla I SvenssonTony L Yaksh
Nov 17, 2005·Molecular and Cellular Biology·Victoria A BeardmoreJ Simon C Arthur

❮ Previous
Next ❯

Citations

Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Donghoon KimSung Joong Lee
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Camilla I Svensson, Tony L Yaksh
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haijun ZhangPatrick M Dougherty
Jan 18, 2011·Pharmacology, Biochemistry, and Behavior·Thacyana T CarvalhoWaldiceu A Verri
Mar 1, 2015·Molecular and Cellular Biochemistry·Francisco A Aguilar-AlonsoMaría Elena Ibarra-Rubio
Oct 6, 2020·Frontiers in Molecular Neuroscience·Prita R AsihArne Ittner
Feb 13, 2020·Frontiers in Immunology·Gilson Gonçalves Dos SantosMaripat Corr
Oct 10, 2020·Annual Review of Pharmacology and Toxicology·C Frank BennettDon W Cleveland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.