Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling

Cellular and Molecular Life Sciences : CMLS
Julhash U KaziLars Rönnstrand

Abstract

SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

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Citations

Sep 27, 2015·Biochimica Et Biophysica Acta·Julhash U KaziLars Rönnstrand
May 9, 2019·Physiological Reviews·Julhash U Kazi, Lars Rönnstrand
Feb 10, 2018·Oncotarget·Haixiu YangDesi Shang
Feb 6, 2016·Oncotarget·Rohit A ChouguleLars Rönnstrand
Feb 20, 2016·Oncotarget·Rohit A ChouguleJulhash U Kazi
Jul 28, 2016·Oncotarget·Sausan A MoharramJulhash U Kazi
Oct 25, 2017·Scientific Reports·Alissa MarhällLars Rönnstrand
Jan 18, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chi-Chen HongChristine B Ambrosone

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