Role of staphylococcal superantigens in upper airway disease

Current Opinion in Allergy and Clinical Immunology
Claus BachertPhilippe Gevaert

Abstract

Chronic rhinosinusitis with nasal polyps often represents a chronic severe inflammatory disease of the upper airways and may serve as a model for lower airway diseases such as late-onset intrinsic asthma. Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis. Nasal polyps (chronic rhinosinusitis with nasal polyps) are characterized by a T-helper-2 dominated cytokine pattern that includes interleukin-5 and formation of immunoglobulin E. This is in contrast to chronic rhinosinusitis without polyps, which exhibits T-helper-1 biased cytokine release. It is now evident that the cytokine environment is decisive regarding the impact of S. aureus derived enterotoxins, which function as superantigens. S. aureus enterotoxin B further shifts the cytokine pattern in nasal polyps toward T-helper-2 cytokines (increases greater than twofold for interleukin-2, interleukin-4 and interleukin-5), but it disfavours the T-regulatory cytokines interleukin-10 and transforming growth factor-beta1. Furthermore, S. aureus derived enterotoxins influence local immunoglobulin synthesis and...Continue Reading

References

Mar 1, 1994·The Journal of Allergy and Clinical Immunology·P K KeithJ Dolovich
Jun 1, 1997·The Journal of Allergy and Clinical Immunology·C BachertC Rudack
Feb 16, 1999·The Journal of Investigative Dermatology·M F HoferD Y Leung
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·P J HaukD Y Leung
Oct 12, 2000·International Journal of Food Microbiology·N Balaban, A Rasooly
Nov 9, 2000·American Journal of Rhinology·C BachertP van Cauwenberge
Apr 11, 2001·The Journal of Allergy and Clinical Immunology·C BachertP van Cauwenberge
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather A CokerHannah J Gould
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Thibaut Van ZeleClaus Bachert
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Claudina Angela Pérez-NovoClaus Bachert
Nov 8, 2006·The Journal of Allergy and Clinical Immunology·Philippe GevaertClaus Bachert
Mar 21, 2007·Chemical Immunology and Allergy·C BachertClaudina Perez-Novo
May 23, 2007·Nature Medicine·Rebecca A BuonpaneDavid M Kranz

❮ Previous
Next ❯

Citations

Feb 9, 2011·Current Allergy and Asthma Reports·Elizabeth K Hoddeson, Sarah K Wise
Apr 19, 2011·Current Allergy and Asthma Reports·Leandra Mfuna-EndamMartin Y Desrosiers
Feb 11, 2012·Current Allergy and Asthma Reports·Andrew ForemanPeter-John Wormald
Mar 9, 2013·Experimental & Molecular Medicine·Purevsuren LosolHae-Sim Park
Sep 15, 2009·Applied and Environmental Microbiology·Avanish K VarshneyBettina C Fries
Jul 26, 2012·Journal of Allergy·Maria L Garcia CruzLuis M Teran
Feb 25, 2011·International Archives of Allergy and Immunology·Claus Bachert
Jul 23, 2013·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Rogério PezatoLuis Carlos Gregório
Feb 23, 2012·PloS One·Lynne R PrinceMoira K B Whyte
Jun 21, 2013·International Journal of General Medicine·Patorn PiromchaiSanguansak Thanaviratananich
May 14, 2010·International Journal of General Medicine·Robert M NaclerioJames N Baraniuk
Sep 29, 2012·Emerging Infectious Diseases·Wellington S TichenorJoseph O Falkinham
Aug 1, 2010·Toxins·Irina V PinchukVictor E Reyes
May 15, 2013·Asia Pacific Allergy·Woo-Jung SongYoon-Seok Chang
Aug 7, 2014·The World Allergy Organization Journal·Rachel HoweGlenis K Scadding
Apr 8, 2009·Current Allergy and Asthma Reports·Wouter HuvenneClaus Bachert
Jul 25, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Petr SchalekA Hahn
Jul 23, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chia-Der LinChih-Ho Lai
Apr 7, 2011·La Revue de médecine interne·A Coste
Feb 7, 2012·International Journal of Pediatric Otorhinolaryngology·Eliza Brożek-MądryAgnieszka Biejat
Nov 22, 2011·Facial Plastic Surgery Clinics of North America·R Peter Manes, Pete S Batra
Oct 1, 2011·The Journal of Allergy and Clinical Immunology·Philippe GevaertClaus Bachert
Sep 3, 2010·The Journal of Allergy and Clinical Immunology·Claus BachertKristel Van Steen
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Mario Sánchez-BorgesFernan Caballero-Fonseca
Aug 8, 2009·The Journal of Allergy and Clinical Immunology·Jean BousquetUNKNOWN Extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asth
Jul 15, 2009·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·N DayP Bonfils
Dec 20, 2015·The Journal of Allergy and Clinical Immunology·Emily P S LamStephen J Till
Mar 13, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Claus Bachert, Daniel L Hamilos
Jun 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J Barnes
Oct 8, 2008·Immunological Reviews·John D Fraser, Thomas Proft
Sep 22, 2012·Allergy·M J EgeE von Mutius
Jan 31, 2012·International Forum of Allergy & Rhinology·Andrew James WoodRichard George Douglas
Jun 21, 2011·Immunological Reviews·Peter J Barnes
Oct 17, 2012·The Laryngoscope·Ahmed Bassiouni, Peter-John Wormald
Aug 24, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Matteo GelardiNicola Principi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.