Role of stem cell-derived exosomes in cancer

Oncology Letters
Junyi WuChunping Jiang

Abstract

Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, secrete exosomes into the extracellular environment, and are significant communicators in the tumor microenvironment. Stem cells are a unique cell population defined by their ability to indefinitely self-renew, differentiate into a variety of cell lines, and form clonal cell populations. Stem cells also secrete large amounts of exosomes, which have demonstrated great potential in a variety of diseases. Increasing evidence has revealed that the mechanism of interaction between stem cells and human tumor cells involves the exchange of biological material through exosomes. In this review, the latest developments in the role of stem cell-derived exosomes in cancer are highlighted.

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Aug 12, 2018·International Journal of Cancer. Journal International Du Cancer·Ursula AltanerovaCestmir Altaner
Aug 6, 2019·Stem Cells·Sanam L Kavari, Khalid Shah
Sep 8, 2020·Stem Cell Reviews and Reports·Sau Har LeeThamil Selvee Ramasamy
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Jan 2, 2021·International Journal of Molecular Sciences·Minyeoung KweonGi Jin Kim
Oct 6, 2018·Biochimica Et Biophysica Acta. Molecular Cell Research·Zubair NizamudeenVirginie Sottile

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