Role of stone analysis in metabolic evaluation and medical treatment of nephrolithiasis

Journal of Endourology
John KourambasG M Preminger

Abstract

Comprehensive metabolic evaluation has become an important aspect of the management of recurrent nephrolithiasis, yet the role of stone analysis is often neglected or perhaps underestimated. The purpose of this study was to determine the role of stone analysis in medical decision making in patients with recurrent nephrolithiasis. We evaluated 100 consecutive stone-forming patients who had undergone compositional stone analysis as well as comprehensive metabolic evaluation at our institution. An analysis of stone composition in relation to metabolic disturbances was performed. Patients were stratified into two groups: calcium and non-calcium stone formers. Patients having non-calcium stones were found to have a metabolic analysis reflecting specific metabolic disorders. Alternatively, patients with calcium stones were heterogeneous with regard to metabolic disorders, but there was a significant likelihood of renal tubular acidosis in those patients with calcium phosphate calculi. On the basis of these results, a simplified metabolic evaluation and nonselective medical therapy based on stone composition was formulated to facilitate assessment, management, and monitoring of stone disease. Compositional stone analysis should be an ...Continue Reading

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Citations

Jun 12, 2013·Current Urology Reports·Adam O Kadlec, Thomas M Turk
May 10, 2005·The Journal of Urology·Michaella E MaloneyGlenn M Preminger
Aug 21, 2013·Journal of Pediatric Urology·Jan K KirejczykWojciech Debek
Jun 8, 2013·World Journal of Urology·Adam O KadlecThomas M T Turk
Dec 3, 2014·European Urology·Andreas SkolarikosChristian Türk
Mar 7, 2007·The Kaohsiung Journal of Medical Sciences·Yii-Her ChouAi-Wen Chang
Oct 30, 2013·BJU International·Ming-Chak Lee, Simon Virgil Bariol
Sep 10, 2015·Mayo Clinic Proceedings·Prince SinghAndrew D Rule
Jul 18, 2003·The American Journal of Medicine·Charles Y C PakMargaret S Pearle
May 23, 2007·Expert Opinion on Pharmacotherapy·Sangtae Park
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Albrecht HesseMatthias Schmidt
Jun 15, 2013·The Journal of Urology·Daniel M MoreiraZeph Okeke
Jun 2, 2016·PloS One·Roswitha SienerUNKNOWN EAU Section of Urolithiasis (EULIS)
Oct 17, 2018·Current Opinion in Urology·Vincent De ConinckOlivier Traxer
Apr 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazumi TaguchiTakahiro Yasui
Sep 16, 2017·Experimental and Therapeutic Medicine·Zhang HeGao Fei
Apr 15, 2003·Current Opinion in Urology·Fernando C Delvecchio, Glenn M Preminger
Dec 19, 2020·International Journal of Clinical Practice·Ahmet GudelogluCenk Yucel Bilen

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