PMID: 3384130Mar 1, 1988Paper

Role of subcortical structures in the development of vascular and neuronal responses of the brain to hypoxia

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
A I Artem'eva

Abstract

Spontaneous impulse activity, local blood flow and oxygen available were recorded in hypoxia in intact and in neuronally isolated cortex in cats. The hypoxia affected all three parameters. The increase in firing rate of spontaneously active neurons was delayed in isolated cortex as compared with the intact one, and the duration of activation phase was prolonged. Two factors seem to induce changes of spontaneous cortical activity in hypoxia: activating effect of subcortical structures (in initial stages of the hypoxia) and own response of the neurons to the oxygen deficiency.

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