Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Peptides
Toshiaki SendoRyozo Oishi

Abstract

The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P < 0.05) increased during paclitaxel infusion. Therefore, substance P rather than histamine may be involved in paclitaxel hypersensitivity.

References

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Citations

Jun 29, 2006·The Cancer Journal·Agnes HenryJacques Descotes
May 5, 2011·European Journal of Pharmacology·Yoko TatsushimaRyozo Oishi
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Hideaki YahataRyozo Oishi
Jun 16, 2012·Expert Opinion on Therapeutic Patents·Miguel MuñozRafael Coveñas
Aug 2, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshinori ItohRyozo Oishi
Jan 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Yoko TatsushimaRyozo Oishi

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