Role of substance P in several models of bladder inflammation

Urological Research
J Luber-NarodR E Carraway

Abstract

Substance P (SP) is a peptide found in the sensory nervous system which has multiple biologic effects including stimulation of muscle contraction, pain nociception, immune cell functions, plasma extravasation and a constellation of inflammatory effects. Here we investigate the role of SP in several animals models of bladder inflammation. Using the female Lewis rat, inflammation was induced using either xylene, lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (polyIC). Inflammation occurred rapidly (4 h) and was maintained in each model for at least 7 days. Each of these protocols decreased the bladder content of immunoreactive SP by approximately 50%, suggesting enhanced release. There was no change in the urinary frequency of these animals over 3 weeks, suggesting that urinary frequency changes are not mediated by acute inflammation. We also found that the SP receptor (NK1) antagonist, (-)CP96345, was unable to block the inflammation produced by polyIC, suggesting that SP is not an obligatory mediator of immune cell stimulation in this model.

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Citations

Dec 4, 2009·Carcinogenesis·Arup BhattacharyaYuesheng Zhang
Jun 24, 1999·The Journal of Urology·D E BjorlingR Saban
Jul 6, 2005·Biological & Pharmaceutical Bulletin·Junping KouQiang Xu
Aug 3, 2011·Journal of Ethnopharmacology·Chen-Xiao ZhangQiu-Xing Cai
Jan 19, 2018·The Journal of Veterinary Medical Science·Atsushi TsukamotoTomo Inomata
Nov 1, 2015·Asian Pacific Journal of Tropical Biomedicine·Raphael Nammahime AlolgaSaid Abasse Kassim
Jan 17, 2002·The Journal of Urology·Jodi L Westropp, C A Tony Buffington

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