PMID: 6972799Aug 3, 1981Paper

Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy

Brain Research
M MorelliG Di Chiara

Abstract

Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.

References

May 28, 1976·Brain Research·M L TappazM Palkovits

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Citations

Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K OssowskaS Wolfarth
Sep 3, 1984·European Journal of Pharmacology·B EllenbroekA Cools
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·M De RyckE K Silbergeld
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·N J Johnson, R Stevens
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·R Santos, E A Carlini
Mar 1, 1994·Neurotoxicology and Teratology·J S MeyerM S Todtenkopf
Aug 25, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·R BruggemanW Timmerman
Nov 2, 2001·Progress in Neurobiology·W R Klemm
Jul 18, 2009·Neuroscience and Biobehavioral Reviews·Wolfgang Löscher
Oct 14, 2016·Frontiers in Pharmacology·Fernanda F PeresVanessa C Abílio
Dec 6, 2017·Environmental Science and Pollution Research International·Leila MohammadzadehBibi Marjan Razavi

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