Role of sugammadex in accelerating postoperative discharge: A meta-analysis

Journal of Clinical Anesthesia
Michele CarronCarlo Ori

Abstract

Sugammadex has been introduced for reversal of neuromuscular blockade (NMB) induced by rocuronium (or vecuronium). Although its efficacy and safety have been established, data are conflicting as to whether it accelerates discharge to the surgical ward compared with neostigmine, which is traditionally used for reversing NMB. The object of this systematic review and meta-analysis was to review the research comparing sugammadex and neostigmine in the context of patient discharge after general anesthesia. Systematic review and meta-analysis. University medical hospital. Five-hundred eighteen patients from six studies were included. A comprehensive search was conducted using PubMed, Web of Science, Google Scholar, and Cochrane Library electronic databases to identify randomized controlled trials written in English. Two reviewers independently selected the studies, extracted data regarding postoperative discharge, and assessed the trials' methodological quality and evidence level. Postoperative discharge time was determined from the operating room (OR) to the postanesthesia care unit (PACU) and from the PACU to the surgical ward. This study was conducted using PRISMA methodology. Time to discharge after NMB reversal with sugammadex o...Continue Reading

Citations

Jul 3, 2018·The Journal of International Medical Research·Young Sung KimYun Hee Kim
Apr 11, 2019·The Laryngoscope·Prok LaosuwanMingkwan Wongyingsinn
Apr 24, 2020·Current Opinion in Anaesthesiology·Eliot Grigg
Apr 24, 2019·Journal of Evaluation in Clinical Practice·Jared C Cohen, Kevin J Latchford
Mar 7, 2020·Journal of Korean Medical Science·Woon Young KimToo Jae Min
Oct 28, 2020·Perioperative Medicine·Federico PiccioniUNKNOWN AIPO, Associazione Italiana Pneumologi Ospedalieri; SIAARTI, Società Italiana di Anestesia Analgesia Rianimazione Terapia In
Mar 23, 2021·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Emily HartmanKatherine Pereira
Aug 14, 2018·Journal of Clinical Anesthesia·Mark C KendallChristopher J Malgieri

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