PMID: 3214168Dec 1, 1988Paper

Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria

Archives of Biochemistry and Biophysics
G A MooreP J O'Brien

Abstract

Incubation of rat liver mitochondria with benzoquinone derivatives in the presence of succinate plus rotenone has been shown to cause NAD(P)H oxidation followed by Ca2+ release. Further investigation revealed: (1)p-Benzoquinone-induced Ca2+ release was not initiated by a collapse of the mitochondrial membrane potential. However, Ca2+ release and subsequent Ca2+ cycling caused limited increased membrane permeability. (2) p-Benzoquinone-induced NAD(P)H oxidation and Ca2+ release were prevented by isocitrate, 3-hydroxybutyrate, and glutamate but not by pyruvate or 2-oxoglutarate. (3) Inhibition of pyruvate and 2-oxoglutarate dehydrogenases by p-benzoquinone was attributed to arylation of the SH groups of the cofactors, CoA and lipoic acid. Isocitrate dehydrogenase was also inhibited by p-benzoquinone, but the cofactors NAD(P)H and Mn2+ protected the enzyme. Glutamate dehydrogenase was not inhibited by p-benzoquinone. (4) Arylation of mitochondrial protein thiols by p-benzoquinone was associated with an inhibition of state 3 respiration, which was attributed to the inactivation of the phosphate translocase. In contrast, state 4 respiration, and the F1.F0-ATPase and ATP/ADP translocase activities were not inhibited. It was concluded...Continue Reading

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Citations

Jan 1, 1990·Chemico-biological Interactions·M WeisP Moldeus
Jan 1, 1991·Chemico-biological Interactions·P J O'Brien
Mar 10, 1993·Biochimica Et Biophysica Acta·M WeisP Moldéus
Jun 23, 1999·Toxicology Letters·D A Stoyanovsky, A I Cederbaum
Jan 1, 1992·Toxicology and Applied Pharmacology·T J MonksD G Graham
Sep 30, 1991·The American Journal of Medicine·H Sies
May 3, 2014·International Journal of Molecular Sciences·Kristien J A LemmensGuido R M M Haenen
Sep 9, 2017·Cell Biology International·Mabel Buelna-ChontalEdmundo Chávez
Jun 1, 1991·Bioscience Reports·M J MacDonald
Dec 1, 1990·Archives of Biochemistry and Biophysics·E Lenartowicz
Apr 1, 1990·Current Opinion in Cell Biology·A R BoobisD S Davies

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