PMID: 11912454Mar 26, 2002Paper

Role of supraspinal alpha1-adrenoceptors for voiding in conscious rats with and without bladder outlet obstruction

The Journal of Urology
Bao Jun GuKarl-Erik Andersson

Abstract

Previous studies have shown that spinal alpha1-adrenoceptors can influence voiding in normal rats and in rats with outlet obstruction. Also, at the supraspinal level such receptors may be involved in voiding control. Therefore, we studied in rats the effects on cystometrography of intracerebroventricular administered alpha1-adrenoceptor antagonists. Continuous cystometry was performed in conscious, freely moving rats with and without bladder outlet obstruction. Cystometric parameters were evaluated before and after intracerebroventricular drug administration. In normal rats intracerebroventricular administration of 8 nmol. kg.-1 prazosin (Pfizer Central Research, Sandwich, United Kingdom) or terazosin (Abbott Laboratories, Abbott Park, Illinois) (nonsubtype selective) caused no change in cystometric parameters. At 24 or 80 nmol. kg.-1 the 2 drugs significantly decreased voiding pressure and increased bladder capacity, voided volume and post-void residual urine volume. Administering vehicle had no effect. In rats with outlet obstruction the drug effects were significantly more pronounced than in normal animals (p <0.05), and urinary retention was produced in 50% of rats receiving prazosin. In normal rats the selective alpha1A-ad...Continue Reading

References

Jan 16, 1995·European Journal of Pharmacology·A S GoetzD L Saussy
Oct 15, 1994·Microscopy Research and Technique·M Sasa, N Yoshimura
Sep 26, 1996·European Journal of Pharmacology·T WadaH Ono
Sep 26, 1997·The Journal of Comparative Neurology·A V Domyancic, D A Morilak
Jun 1, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·B J GuK E Andersson

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Citations

Dec 10, 2003·Urology·Karl Erik Andersson
Dec 16, 2006·International Journal of Clinical Practice. Supplement·K-E Andersson
Oct 8, 2008·Neurourology and Urodynamics·Zhong ChenKarl-Erik Andersson
Feb 9, 2006·British Journal of Pharmacology·Gordon McMurrayAlasdair M Naylor

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