PMID: 11927830Apr 3, 2002Paper

Role of surface roughness of titanium versus hydroxyapatite on human bone marrow cells response

Journal of Spinal Disorders & Techniques
Panagiotis G Korovessis, D D Deligianni

Abstract

This study was designed to assess human bone marrow cell response and particularly cell adhesion, proliferation, and differentiation, when cultured in vitro on titanium alloy and hydroxyapatite with different values of surface roughness. A further aim was to compare the cell response on the two materials, currently used in spinal surgery. Cell adhesion was determined after 0.5, 2, 4, and 18 hours of incubation; proliferation after 8, 11, 14, and 16 days of culture; and differentiation was evaluated with the expression of alkaline phosphatase activity after 8 and 16 days of culture. This study showed that bone marrow cells grew faster on titanium alloy than on hydroxyapatite, although fewer cells attached to titanium, compared to those attached to hydroxyapatite. No statistically significant difference was observed as the expression of alkaline phosphatase activity on hydroxyapatite and titanium alloy of the same roughness. Cell adhesion, proliferation, and differentiation are dependent on surface roughness of the biomaterial, and all three increased as the roughness of titanium alloy increased. Conclusively, surface roughness of titanium and hydroxyapatite significantly influences bone marrow cell response, and therefore these ...Continue Reading

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Citations

Dec 25, 2007·Journal of Materials Science. Materials in Medicine·David M PickupRobert J Newport
Apr 10, 2012·Journal of Materials Science. Materials in Medicine·Petros A KokkinosDespina D Deligianni
Mar 17, 2005·Biomaterials·Veronica BorsariRoberto Giardino
Aug 16, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Veronica BorsariRoberto Giardino
Aug 5, 2004·Journal of Biomedical Materials Research. Part a·Robert M LevenDale R Sumner
Jun 15, 2007·Journal of Biomedical Materials Research. Part a·John D JarrellJeffrey R Morgan
Jan 11, 2007·Journal of Biomedical Materials Research. Part a·James E HoKevin E Healy
Mar 30, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Nianli Zhang, David H Kohn
Nov 30, 2004·Biomolecular Engineering·Her-Hsiung HuangFang-Lung Chen
Jun 20, 2006·Colloids and Surfaces. B, Biointerfaces·A Méndez-VilasM L González-Martín
Sep 27, 2005·Micron : the International Research and Review Journal for Microscopy·Franchi MarcoOttani Vittoria
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Alieh AminianKurosch Rezwan

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