Role of surgery in children with rhabdomyosarcoma

Medical and Pediatric Oncology
Erica L Schalow, Bruce H Broecker

Abstract

Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma of childhood. Historically, surgery has played a central role in the management of children with this tumor, though with surgery alone survival rates were poor. With current multimodal (surgery, radiotherapy and chemotherapy) treatment of these patients, survival has dramatically improved and, with this improvement, there has been an evolution of the role of surgery in the management of this condition. The contemporary published literature (English) regarding surgical aspects of pediatric rhabdomyosarcoma was reviewed and evaluated. Multimodal therapy has improved the survival of children with RMS from 25% in 1970 to greater than 70% today. Surgical procedures for childhood RMS today are less apt to be exenterative or mutilating than those employed thirty years ago. Surgery plays a vital role in the diagnosis and treatment of children with RMS. This role has evolved in the context of multimodal therapy and improved survival to an emphasis on less radical procedures with decreased morbidity.

References

Feb 1, 1990·Journal of Pediatric Surgery·M P LaQuagliaP R Exelby
Jan 15, 1988·Cancer·H M MaurerJ Ortega
Nov 1, 1968·Cancer·A Keyhani, R J Booher
Jun 1, 1995·The Annals of Thoracic Surgery·B K TemeckH I Pass
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W CristR Heyn
Nov 1, 1994·British Journal of Cancer·C K YeungJ Pritchard
Feb 1, 1994·Journal of Pediatric Surgery·E S WienerE Gehan
Mar 1, 1993·Cancer·H M MaurerJ Herrmann
Jan 1, 1995·World Journal of Urology·M FischR Hohenfellner
Jul 1, 1995·Cancer·G W HolcombE S Wiener
Sep 19, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S NagC Bauer
Feb 7, 1998·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·N C SaenzM P LaQuaglia
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H MartelliM C Stevens
Mar 31, 2000·Surgical Endoscopy·J H WaldhausenR S Sawin
Jun 29, 2000·Journal of Pediatric Surgery·H L NevilleM I Ross
Feb 24, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·J H WillmanC M Coffin
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson

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Citations

Mar 3, 2004·Current Treatment Options in Oncology·Matthew T HartingRichard J Andrassy
Oct 10, 2006·Future Oncology·Piotr Czauderna
Jan 6, 2009·Journal of the American Animal Hospital Association·Andrew D MillerBarry Cooper
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jade J Wong-You-CheongIsabell A Sesterhenn
Jan 14, 2011·Auris, Nasus, Larynx·Paolo GradoniGian Carlo Izzi
Jul 27, 2010·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·J C BolgerP Harrington
Jan 22, 2008·Current Problems in Cancer·Arnold C Paulino, Mehmet Fatih Okcu
Jun 15, 2005·Dermatologic Therapy·Davis FarvoldenKaren Wiss
Sep 6, 2007·Pediatric Hematology and Oncology·Eudaldo M López-Tomassetti FernándezLucio Díaz Flores
Mar 30, 2004·Pediatric Blood & Cancer·Giulio J D'Angio

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