PMID: 7007709Sep 1, 1980Paper

Role of sympathetic nerve inhibition and body sodium-volume state in the antihypertensive action of clonidine in essential hypertension

Kidney International
V M CampeseS G Massry

Abstract

A simultaneous analysis of the interrelationships between mean blood pressure (MBP), plasma catecholamines, plasma renin activity (PRA) and aldosterone, exchangeable body sodium, and blood volume was carried out before and after acute and chronic administration of clonidine in 15 patients with essential hypertension, in order to further elucidate the mechanism(s) of action of this drug. After a single oral dose of 200 microgram, clonidine produced a significant fall in MBP, heart rate, plasma norepinephrine (NE), PRA, and aldosterone. There were significant correlations (P < 0.01) between NE and MBP, but not between PRA or aldosterone and MBP both before and after the ingestion of clonidine. Furthermore, there was a significant correlation (P < 0.05) between the magnitude of fall of plasma NE and change in MBP. After 6 weeks of treatment, conidine at a dose of 960 +/- 80 microgram/day produced a significant decrement in MBP and NE, but not in PRA and aldosterone; with upright posture, the magnitude of the fall in MBP was significantly greater (P < 0.01), and the rise in plasma NE was significantly smaller (P < 0.01) after chronic clonidine treatment. There was also a significant fall (P < 0.01) in exchangeable sodium and plasma...Continue Reading

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Citations

May 1, 1991·Journal of Clinical Pharmacology·D D GretlerM B Murphy
Jan 7, 1984·Lancet·M A WeberJ L Lipson
Feb 19, 2011·International Journal of Hypertension·Vito M CampeseJeanie Park
Oct 5, 1984·The American Journal of Medicine·M A Weber, J I Drayer
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·E LucchiniC Beretta-Piccoli
Feb 1, 1983·Chest·V M Campese, S G Massry
Jul 1, 1982·Pediatric Annals·L Reisman, R V Selden
Sep 23, 1988·The American Journal of Medicine·W B Abrams
Mar 1, 1987·Journal of Clinical Pharmacology·R ZimlichmanH R Keiser
Jan 1, 1987·Journal of Clinical Pharmacology·V Plänitz
Apr 7, 2007·Journal of Cardiovascular Pharmacology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jul 3, 2020·Frontiers in Medicine·Ekamol TantisattamoAlpesh Amin
Jan 1, 1986·Acta Medica Scandinavica. Supplementum·B E Karlberg, L Hedman

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