Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue

Arteriosclerosis, Thrombosis, and Vascular Biology
Sophie N SaxtonAnthony M Heagerty

Abstract

Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3-adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicated in this effect and may stimulate the release of the vasodilator adiponectin from adipocytes. Understanding the mechanisms responsible is vital for determining how PVAT may modify vascular resistance in vivo. Electrical field stimulation profiles of healthy C57BL/6J mouse mesenteric resistance arteries were characterized using wire myography. During electrical field stimulation, PVAT elicits a reproducible anticontractile effect, which is endothelium independent. To demonstrate the release of an anticontractile factor, the solution surrounding stimulated exogenous PVAT was transferred to a PVAT-denuded vessel. Post-transfer contractility was significantly reduced confirming that stimulated PVAT releases a transferable anticontractile factor. Sympathetic denervation of PVAT using tetrodotoxin or 6-hydroxydopamine completely abolished the anticontractile effect. β3-adrenoceptor antagonist SR59203A reduced the anticontractile effect, although the PVAT remained overall anticontractile. When the an...Continue Reading

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Citations

Feb 13, 2019·Cardiovascular Drugs and Therapy·Sophie N SaxtonAnthony M Heagerty
Apr 25, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun ChengYan Yang
Jul 25, 2019·Physiological Reviews·Sophie N SaxtonAnthony M Heagerty
Dec 24, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong S LuAlan Daugherty
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lin ChangY Eugene Chen
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Jul 11, 2020·Experimental Physiology·S N SaxtonS B Withers
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Sep 2, 2018·Cardiovascular Drugs and Therapy·Chak Kwong ChengYu Huang
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Jan 15, 2019·Journal of the American Heart Association·Ryosuke NumaguchiNobuyoshi Kawaharada
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ha Won KimNeal L Weintraub
Nov 19, 2018·Cellular and Molecular Life Sciences : CMLS·Maoqing YePingjin Gao
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Sophie N SaxtonAnthony M Heagerty
Mar 10, 2021·Cardiovascular Drugs and Therapy·Sophie N SaxtonAnthony M Heagerty
Mar 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Shigeo GodoHiroaki Shimokawa
Apr 2, 2021·Circulation Research·Mascha KoenenJames R Sowers
Mar 30, 2021·Journal of the American Heart Association·Takuma MikamiNobuyoshi Kawaharada
Jul 10, 2021·Frontiers in Pharmacology·Xinzhi LiYi Zhun Zhu

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