PMID: 9431853Feb 12, 1998Paper

Role of sympathetic nerves for the stimulation of the renin system by angiotensin II receptor blockade

Journal of Hypertension
C WagnerA Kurtz

Abstract

To assess the relevance of sympathetic nerves for the stimulation of renin secretion and renin gene expression during effective angiotensin II type 1 receptor blockade in vivo. Male Sprague-Dawley rats were treated with the angiotensin II type 1-receptor blocker losartan (40 mg/kg) for 3 days. To examine the role of renal sympathetic nerves in the stimulation of the renin system by losartan, left kidneys were denervated 4 days prior to the treatment with losartan. Also, to examine the role of circulating catecholamines in the stimulation of the renin system by losartan, the animals were administered a combination treatment of losartan with the beta1-adrenoreceptor blocker metoprolol (50 mg/kg per day) for 3 days. Losartan treatment increased plasma renin activity about sevenfold and renal renin messenger RNA (mRNA) levels about fivefold and decreased systolic blood pressure from 118 to 95 mmHg. Administration of losartan elevated renin mRNA both in the innervated and in the denervated kidneys to the same level as it did in kidneys of normal animals. Losartan treatment increased plasma renin activity and renal renin mRNA levels in the beta1-blocker-treated rats to the same extent as it did in animals administered losartan only. ...Continue Reading

References

Jun 5, 1975·The New England Journal of Medicine·W A Pettinger, H C Mitchell
Dec 1, 1992·Clinical and Experimental Pharmacology & Physiology·Y ZhangG Read
Oct 1, 1990·Physiological Reviews·E HackenthalR Taugner
Dec 1, 1988·Journal of Cardiovascular Pharmacology·A KurtzI Cavero
Aug 1, 1988·The Journal of Clinical Investigation·A KurtzJ A Fischer
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C E BurnhamK R Lynch
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·K SchrickerA Kurtz
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·M ItoT M Coffman
Oct 1, 1993·Journal of Hypertension·S HolmerA Kurtz
Oct 1, 1996·Journal of the American Society of Nephrology : JASN·T MatsusakaI Ichikawa

❮ Previous
Next ❯

Citations

Aug 5, 1998·Current Opinion in Nephrology and Hypertension·C Wagner, A Kurtz
Feb 11, 2003·Critical Care Medicine·Michael BucherArmin Kurtz
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Marta H KriegerJose E Krieger
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M L DraperJ C Rose
Feb 8, 2002·American Journal of Physiology. Renal Physiology·K HöcherlA Kurtz
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J S RosnesJ C Rose

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.