Role of systemic inflammation scores in pulmonary metastasectomy for colorectal cancer

Thoracic Cancer
Tommaso Claudio Mineo, Federico Tacconi

Abstract

Patients with pulmonary metastases from colorectal cancer can benefit from surgical removal. However, the biological determinants of postsurgical outcome are not completely elucidated. We evaluated the role of host systemic inflammation status in this setting. The modified Glasgow prognostic score (based on serum C-reactive protein and albumin levels) and the neutrophil-to-lymphocyte (NTL) ratio were obtained from 44 patients who received curative-intent metastasectomy, and were used as indicators of systemic inflammation status. We tested the impact of both of these parameters on overall survival (OS) and progression-free survival (PFS), as well as their correlation with other well-known prognosticators. Five-year PFS and OS rates were 18% and 49%, respectively. At univariate analysis, multiple metastases, disease-free interval <36 months, and a Glasgow score of 2 (P = 0.031) were significantly associated to a worse PFS rate. A NTL ratio >3 predicted disease progression in the short-term (P = 0.036), but the effect on late events was weaker (P = 0.079). Factors associated with worse OS were multiple metastasis (P = 0.002), elevated carcinoembryonic antigen (P = 0.009), a Glasgow score of 2 (P = 0.029), and a faster metastasis ...Continue Reading

References

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Citations

Jul 8, 2017·International Journal of Molecular Sciences·Tommaso Claudio MineoVincenzo Ambrogi
Mar 28, 2019·Frontiers in Microbiology·Jayashree A Chandrasekharan, Neelam Sharma-Walia
Jun 12, 2020·Cancers·Alena LiskovaPeter Kubatka
Jul 11, 2019·Oncology Letters·Katarzyna JakubowskaWaldemar Famulski
Oct 21, 2015·Interactive Cardiovascular and Thoracic Surgery·Tommaso C Mineo, Federico Tacconi

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