Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity.

Frontiers in Immunology
Chek Meng PohLisa F P Ng

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-delta (γδ) T cells, can also contribute to protective immunity, but their effect is not actuated during the natural course of infection. This review serves to consolidate and discuss the multifaceted roles of these T cell subsets during acute and chronic phases of CHIKV infection, and highlight gaps in the current literature. Importantly, the unique characteristics of skin-resident memory T cells are outlined to propose novel prophylactic strategies that utilize their properties to provide adequate, lasting protection.

References

Nov 1, 1969·The American Journal of Tropical Medicine and Hygiene·S NimmannityaM R Margiotta
Oct 3, 2001·Journal of Virology·A M PowersS C Weaver
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent JohnstonEugene C Butcher
Jan 1, 1955·Transactions of the Royal Society of Tropical Medicine and Hygiene·W H LUMSDEN
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin F ChongRobert C Fuhlbrigge
Aug 19, 2007·The Journal of General Virology·Ann M Powers, Christopher H Logue
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Scott N Mueller, Rafi Ahmed
Jun 9, 2009·Nature Reviews. Microbiology·Kirk W DeitschJames R Stringer
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Erin StaplesAnn M Powers
Sep 10, 2009·Microbes and Infection·Yiu-Wing KamLisa F P Ng
Feb 4, 2010·The Journal of Experimental Medicine·Clémentine SchilteMatthew L Albert
Feb 25, 2010·The Journal of Clinical Investigation·Karine LabadiePierre Roques
Apr 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Jacques HoarauPhilippe Gasque
Jun 4, 2010·Journal of Virology·Joy GardnerAndreas Suhrbier
Jun 17, 2010·Nature Reviews. Microbiology·Olivier Schwartz, Matthew L Albert
Mar 23, 2012·Proceedings. Biological Sciences·Philip L F JohnsonRustom Antia
Apr 24, 2012·Gastroenterology·Gerhard WingenderMitchell Kronenberg
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gyehwa ShinJoseph Marcotrigiano
Nov 8, 2012·Mucosal Immunology·L S Cauley, L Lefrançois
Dec 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teck-Hui TeoLisa F P Ng
Dec 12, 2012·Annual Review of Immunology·Scott N MuellerWilliam R Heath
May 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fok-Moon LumLisa F P Ng
Aug 21, 2013·Immunological Reviews·Haina Shin, Akiko Iwasaki
Dec 10, 2013·Cell Reports·Joshua M Horne-DebetsMichelle N Wykes
Jul 25, 2014·PLoS Neglected Tropical Diseases·James Weger-LucarelliJorge E Osorio
Sep 12, 2014·Journal of Virology·David HallengärdPeter Liljeström
Nov 26, 2014·Viruses·Lark L CoffeyScott C Weaver
Dec 10, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristina S BurrackThomas E Morrison

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