PMID: 8588092Nov 1, 1995Paper

Role of T-cells, virus neutralising antibodies and complement-mediated antibody lysis in the immune response against equine herpesvirus type-1 (EHV-1) infection of C3H (H-2k) and BALB/c (H-2d) mice

Research in Veterinary Science
D G AlberA Stokes

Abstract

The suitability of C3H (H-2k) and BALB/c (H-2d) mice for use as small animal models to study immunity to EHV-1 was assessed. An in vitro T cell response mediated by both CD4+ and CD8+ T cells was detected both during the acute phase of infection and after challenge with a second dose of EHV-1 at two months in lymphocyte populations taken from the spleens of both types of mouse. The responses were apparent until at least 61 days after the primary inoculation. After challenge, T cells from mice previously infected with EHV-1 responded by as early as day 3 after infection and higher levels of T cell proliferation were reached than in mice undergoing a primary infection. Immunological cross-reactivity with the closely related virus, EHV-4 was detected and some activity against herpes simplex virus type-1 (HSV-1) was observed during the acute phase of infection. T cell responses were detected in the draining cervical lymph nodes but not in the inguinal lymph nodes of the mice and these were the primary sites of T cell activation. Complement-dependent virus neutralising antibodies were present by day 8 after infection. These antibodies were also able to lyse EHV-1 infected target cells in vitro. Complement-independent virus neutralis...Continue Reading

References

Jan 1, 1992·Archives of Virology·H J FieldR de la Fuente
Nov 1, 1988·The Journal of General Virology·J A López-GuerreroM Fresno
Feb 1, 1993·The Journal of Veterinary Medical Science·M InazuH Iwai

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Citations

Jul 16, 2013·Archives of Virology·Carolina ZanuzziCecilia Galosi
Dec 5, 2009·The Journal of Veterinary Medical Science·Mi Htay Htay YuHideto Fukushi

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