Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor beta chain transgenic mouse

European Journal of Immunology
G FreerH Hengartner

Abstract

During most immune responses, T cells help antigen-specific B cells to make antibodies against the antigen. One of the contributions of T cells to antibody production is the induction of isotype switching from IgM to IgG, which is the most abundant isotype in blood serum during recall responses. Other features of memory responses are faster kinetics and higher titers of antibody in the serum. What causes a primary immune response to be different from a secondary is not yet very clear and, particularly, the influence of precursor frequencies of T and B cells on memory responses still remains to be answered. To address this issue, a transgenic (tg) mouse line (ADA) was developed; it expresses the beta chain (V beta 2) of a major histocompatibility complex class II-restricted T cell receptor (TcR) specific for the glycoprotein (G) of vesicular stomatitis virus (VSV) serotype Indiana (VSV-IND). These mice exhibit an increased precursor frequency of VSV-specific CD4+ T cells that leads to enhanced neutralizing IgG production against VSV in vivo in unprimed mice. The data indicate that increased frequency of naive specific helper T cells alone may account for features of a memory phenotype such as high titer of antibodies and isotype...Continue Reading

References

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Citations

Apr 1, 1996·Current Opinion in Immunology·M G McHeyzer-WilliamsM M Davis
Jun 1, 1996·Current Opinion in Immunology·M G McHeyzer-Williams
Oct 25, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Manuel ComabellaJan D Lünemann
Mar 27, 2001·European Journal of Immunology·F GranucciP Ricciardi-Castagnoli
Jan 1, 1996·Annual Review of Immunology·R M ZinkernagelH Hengartner
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deepta BhattacharyaIrving L Weissman

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